User profiles for Joel Simrén

Joel Simrén

University of Gothenburg
Verified email at gu.se
Cited by 1533

Transitioning from cerebrospinal fluid to blood tests to facilitate diagnosis and disease monitoring in Alzheimer's disease

…, NJ Ashton, TK Karikari, J Simrén… - Journal of internal …, 2021 - Wiley Online Library
Alzheimer’s disease (AD) is increasingly prevalent worldwide, and disease‐modifying
treatments may soon be at hand; hence, now, more than ever, there is a need to develop …

An update on fluid biomarkers for neurodegenerative diseases: recent success and challenges ahead

J Simrén, NJ Ashton, K Blennow… - Current opinion in …, 2020 - Elsevier
Highlights • Protein biomarkers in cerebrospinal fluid now define Alzheimer’s disease (AD).
• New ultrasensitive techniques have enabled promising replication in blood. • This would …

Fluid biomarkers in Alzheimer's disease

J Simrén, A Elmgren, K Blennow… - Advances in clinical …, 2023 - Elsevier
Alzheimer's disease (AD) characterization has progressed from being indexed using clinical
symptomatology followed by neuropathological examination at autopsy to in vivo signatures …

The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's disease

J Simrén, A Leuzy, TK Karikari, A Hye… - Alzheimer's & …, 2021 - Wiley Online Library
… First authors Joel Simrén and Antoine Leuzy contributed … First authors Joel Simrén and Antoine
Leuzy contributed … First authors Joel Simrén and Antoine Leuzy contributed equally to this …

[HTML][HTML] Plasma biomarkers for Alzheimer's disease in relation to neuropathology and cognitive change

…, NJ Ashton, K Blennow, H Zetterberg, J Simrén… - Acta …, 2022 - Springer
Plasma biomarkers related to amyloid, tau, and neurodegeneration (ATN) show great
promise for identifying these pathological features of Alzheimer’s Disease (AD) as shown by …

[HTML][HTML] Neurochemical signs of astrocytic and neuronal injury in acute COVID-19 normalizes during long-term follow-up

N Kanberg, J Simrén, A Edén, LM Andersson… - …, 2021 - thelancet.com
Background Neurologic manifestations are well-recognized features of coronavirus disease
2019 (COVID-19). However, the longitudinal association of biomarkers reflecting CNS …

MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's disease

…, I Chrysidou, AM Arranz, A Sierksma, J Simrén… - Science, 2023 - science.org
Neuronal cell loss is a defining feature of Alzheimer’s disease (AD), but the underlying
mechanisms remain unclear. We xenografted human or mouse neurons into the brain of a mouse …

Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's disease

…, AK Singh, TK Karikari, J Simrén… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction This study involved a parallel comparison of the diagnostic and longitudinal
monitoring potential of plasma glial fibrillary acidic protein (GFAP), total tau (t‐tau), …

Establishment of reference values for plasma neurofilament light based on healthy individuals aged 5–90 years

J Simrén, U Andreasson, J Gobom… - Brain …, 2022 - academic.oup.com
The recent development of assays that accurately quantify neurofilament light, a neuronal
cytoskeleton protein, in plasma has generated a vast literature supporting that it is a sensitive, …

Effects of pre‐analytical procedures on blood biomarkers for Alzheimer's pathophysiology, glial activation, and neurodegeneration

…, A Snellman, M Sauer, J Simrén… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction We tested how tube types (ethylenediaminetetraacetic acid [EDTA], serum, lithium
heparin [LiHep], and citrate) and freeze–thaw cycles affect levels of blood biomarkers for …