Bacteria assume distinct lifestyles during the planktonic and biofilm modes of growth. Increased
levels of the intracellular messenger c-di-GMP determine the transition from planktonic …

Drug resistance and tolerance greatly diminish the therapeutic potential of antibiotics against
pathogens. Antibiotic tolerance by bacterial biofilms often leads to persistent infections, but …

Bacterial biofilms are responsible for a wide range of persistent infections. In the clinic,
diagnosis of biofilm-associated infections relies heavily on culturing methods, which fail to detect …

Microbial infections of the cornea are potentially devastating and can result in permanent
visual loss or require vision-rescuing surgery. In recent years, there has been an increasing …

The bacterial messenger cyclic diguanylate monophosphate (c-di-GMP) binds to various
effectors, the most common of which are single-domain PilZ proteins. These c-di-GMP effectors …

The alternative sigma factor RpoN regulates many cell functions, such as motility, quorum
sensing, and virulence in the opportunistic pathogen Pseudomonas aeruginosa (P. aeruginosa…

Diversity has a key role in the dynamics and resilience of communities and both interspecific
(species) and intraspecific (genotypic) diversity can have important effects on community …

The nucleotide signalling molecule bis‐(3'‐5’)‐cyclic dimeric guanosine monophosphate (c‐di‐
GMP ) plays an essential role in regulating microbial virulence and biofilm formation. C‐…

Mixed-species biofilms display a number of emergent properties, including enhanced
antimicrobial tolerance and communal metabolism. These properties may depend on interspecies …

Pseudomonas aeruginosa is a Gram-negative bacterium that is able to survive and adapt in
a multitude of niches as well as thrive within many different hosts. This versatility lies within …