[HTML][HTML] Indian medicinal herbs and formulations for Alzheimer's disease, from traditional knowledge to scientific assessment
Cognitive impairment, associated with ageing, stress, hypertension and various neurodegenerative
disorders including Parkinson’s disease and epilepsy, is a major health issue. The …
disorders including Parkinson’s disease and epilepsy, is a major health issue. The …
Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model
J Mehla, KH Reeta, P Gupta, YK Gupta - Life sciences, 2010 - Elsevier
AIM: Epilepsy as well as chronic use of most antiepileptic drugs predisposes to cognitive
impairment. Curcumin has been reported to possess antioxidant, anticonvulsant as well as …
impairment. Curcumin has been reported to possess antioxidant, anticonvulsant as well as …
Curcumin is protective against phenytoin-induced cognitive impairment and oxidative stress in rats
KH Reeta, J Mehla, YK Gupta - Brain research, 2009 - Elsevier
The present study investigates the effect of chronic curcumin administration on phenytoin-induced
cognitive impairment and oxidative stress in rats. Male Wistar rats were administered …
cognitive impairment and oxidative stress in rats. Male Wistar rats were administered …
Age-dependent behavioral and biochemical characterization of single APP knock-in mouse (APPNL-GF/NL-GF) model of Alzheimer's disease
J Mehla, SG Lacoursiere, V Lapointe… - Neurobiology of …, 2019 - Elsevier
Saito et al developed a novel amyloid precursor protein (APP) knock-in mouse model (APP
NL-GF ) for Alzheimer's disease (AD) to overcome the problem of overexpression of APP in …
NL-GF ) for Alzheimer's disease (AD) to overcome the problem of overexpression of APP in …
Streptozotocin-induced sporadic Alzheimer's disease: selection of appropriate dose
J Mehla, M Pahuja, YK Gupta - Journal of Alzheimer's Disease, 2013 - content.iospress.com
The long term effect of single (day 1) and twice (day 1 and 3) injections of intracerebroventricular
(ICV) streptozotocin (STZ) at the doses of 1 and 3 mg/kg on the cognitive functions of …
(ICV) streptozotocin (STZ) at the doses of 1 and 3 mg/kg on the cognitive functions of …
Hydroalcoholic extract of Zizyphus jujuba ameliorates seizures, oxidative stress, and cognitive impairment in experimental models of epilepsy in rats
The anticonvulsant effect of the hydroalcoholic extract of Zizyphus jujuba (HEZJ) fruit (100,
250, 500, and 1000mg/kg, orally) was evaluated in experimental seizure models in rats. The …
250, 500, and 1000mg/kg, orally) was evaluated in experimental seizure models in rats. The …
Ameliorative effects of nutraceuticals in neurological disorders
NB Chauhan, J Mehla - Bioactive nutraceuticals and dietary supplements in …, 2015 - Elsevier
Normal aging of the brain involves an interplay of heterogeneous cellular and molecular
events, which when aggravated tend to switch normal aging of the brain to the pathological …
events, which when aggravated tend to switch normal aging of the brain to the pathological …
Experimental induction of type 2 diabetes in aging-accelerated mice triggered Alzheimer-like pathology and memory deficits
J Mehla, BC Chauhan… - Journal of Alzheimer's …, 2014 - content.iospress.com
Alzheimer's disease (AD) is an age-dependent neurodegenerative disease constituting~ 95%
of late-onset non-familial/sporadic AD, and only~ 5% accounting for early-onset familial AD…
of late-onset non-familial/sporadic AD, and only~ 5% accounting for early-onset familial AD…
Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in …
KH Reeta, J Mehla, M Pahuja, YK Gupta - Pharmacology Biochemistry and …, 2011 - Elsevier
The present study investigates the interaction of curcumin with four antiepileptic drugs (AEDs)
in male Wistar rats. In the first protocol, seizures were induced using pentylenetetrazole (…
in male Wistar rats. In the first protocol, seizures were induced using pentylenetetrazole (…
[HTML][HTML] Prenatal noise stress impairs HPA axis and cognitive performance in mice
Noise stress is a common environmental pollutant whose adverse effect on offspring
performance has been less studied. This study was novel in terms of using “noise” as a prenatal …
performance has been less studied. This study was novel in terms of using “noise” as a prenatal …