In the unicellular eukaryote Saccharomyces cerevisiae, Cln3–cyclin-dependent kinase
activity enables Start, the irreversible commitment to the cell division cycle. However, the …

Macrocyclic peptides (MPs) have positioned themselves as a privileged class of compounds
for the discovery of therapeutics and development of chemical probes. Aided by the …

Aptamers are oligonucleotide ligands, either RNA or ssDNA, selected for high-affinity binding
to molecular targets, such as small organic molecules, proteins or whole microorganisms. …

Metabolic heterogeneity between individual cells of a population harbors significant
challenges for fundamental and applied research. Identifying metabolic heterogeneity and …

Galactooligosaccharides (GOS) are prebiotic compounds synthesized from lactose using
bacterial enzymes and are known to stimulate growth of beneficial bifidobacteria in the human …

ω-Transaminases are enzymes that can introduce an amino group in industrially interesting
compounds. We determined crystal structures of two (S)-selective ω-transaminases, one …

The incorporation of impurities during protein crystallization is one of the main obstacles
that prevents the growth of high quality crystals. Mass transport has been shown to affect the …

DAT2 is a member of the diacyl trehalose family (DAT) of antigenic glycolipids located in the
mycomembrane of Mycobacterium tuberculosis (Mtb). Recently it was shown that the …

Selective modification of carbohydrate residues in glycopeptides is highly relevant as a tool
in glycobiology. In particular, oxidation allows for subsequent ligation with a label or handle …

The last decade has witnessed the reawakening of cancer metabolism as a therapeutic
target. In particular, inhibition of pyruvate dehydrogenase kinase (PDK) holds remarkable …