Glioblastoma multiforme (GBM) comprises several molecular subtypes, including proneural
GBM. Most therapeutic approaches targeting glioma cells have failed. An alternative strategy …

Cancers develop in complex tissue environments, which they depend on for sustained
growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor …

Metastasis is a multistage process that requires cancer cells to escape from the primary
tumour, survive in the circulation, seed at distant sites and grow. Each of these processes …

Effective immunotherapy promotes the killing of cancer cells by cytotoxic T cells. This requires
not only that cancer-specific T cells be generated, but also that these T cells physically …

This review provides a comprehensive analysis of the current therapies targeting the TME,
combining a discussion of the underlying basic biology with clinical evaluation of different …

INTRODUCTION Therapies targeted against the tumor microenvironment (TME) represent a
promising approach for treating cancer. This appeal arises in part from the decreased …

Cancers represent complex ecosystems comprising tumor cells and a multitude of non-cancerous
cells, embedded in an altered extracellular matrix. The tumor microenvironment (TME) …

The brain tumor microenvironment (TME) is emerging as a critical regulator of cancer
progression in primary and metastatic brain malignancies. The unique properties of this organ …

Brain malignancies encompass a range of primary and metastatic cancers, including low-grade
and high-grade gliomas and brain metastases (BrMs) originating from diverse …

Innate immune cells can constitute a substantial proportion of the cells within the tumor
microenvironment and have been associated with tumor malignancy in patients and animal …