User profiles for Johanna Lepeule
 | johanna lepeuleINSERM Verified email at univ-grenoble-alpes.fr Cited by 7428 |
Chronic exposure to fine particles and mortality: an extended follow-up of the Harvard Six Cities study from 1974 to 2009
Background: Epidemiologic studies have reported associations between fine particles (aerodynamic
diameter ≤ 2.5 µm; PM 2.5 ) and mortality. However, concerns have been raised …
diameter ≤ 2.5 µm; PM 2.5 ) and mortality. However, concerns have been raised …
[PDF][PDF] DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis
Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …
environmental impacts on human disease. Maternal smoking in pregnancy remains an …
Air pollution and gene-specific methylation in the Normative Aging Study: association, effect modification, and mediation analysis
The mechanisms by which air pollution has multiple systemic effects in humans are not fully
elucidated, but appear to include inflammation and thrombosis. This study examines …
elucidated, but appear to include inflammation and thrombosis. This study examines …
Ambient air pollution and low birthweight: a European cohort study (ESCAPE)
…, M Korek, U Krämer, A Lerchundi, J Lepeule… - The lancet Respiratory …, 2013 - thelancet.com
Background Ambient air pollution has been associated with restricted fetal growth, which is
linked with adverse respiratory health in childhood. We assessed the effect of maternal …
linked with adverse respiratory health in childhood. We assessed the effect of maternal …
Maternal exposure to particulate air pollution and term birth weight: a multi-country evaluation of effect and heterogeneity
Background: A growing body of evidence has associated maternal exposure to air pollution
with adverse effects on fetal growth; however, the existing literature is inconsistent. …
with adverse effects on fetal growth; however, the existing literature is inconsistent. …
Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure
Background: Prenatal exposure to air pollution is considered to be associated with adverse
effects on child health. This may partly be mediated by mechanisms related to DNA …
effects on child health. This may partly be mediated by mechanisms related to DNA …
Epigenetic influences on associations between air pollutants and lung function in elderly men: the normative aging study
Background: Few studies have been performed on pulmonary effects of air pollution in the
elderly—a vulnerable population with low reserve capacity—and mechanisms and …
elderly—a vulnerable population with low reserve capacity—and mechanisms and …
LFMM 2: fast and accurate inference of gene-environment associations in genome-wide studies
K Caye, B Jumentier, J Lepeule… - Molecular biology and …, 2019 - academic.oup.com
Gene-environment association (GEA) studies are essential to understand the past and
ongoing adaptations of organisms to their environment, but those studies are complicated by …
ongoing adaptations of organisms to their environment, but those studies are complicated by …
Development of West-European PM2. 5 and NO2 land use regression models incorporating satellite-derived and chemical transport modelling data
Satellite-derived (SAT) and chemical transport model (CTM) estimates of PM 2.5 and NO 2
are increasingly used in combination with Land Use Regression (LUR) models. We aimed to …
are increasingly used in combination with Land Use Regression (LUR) models. We aimed to …
Prenatal particulate air pollution and DNA methylation in newborns: an epigenome-wide meta-analysis
…, I Annesi-Maesano, J Lepeule… - Environmental …, 2019 - ehp.niehs.nih.gov
Background: Prenatal exposure to air pollution has been associated with childhood
respiratory disease and other adverse outcomes. Epigenetics is a suggested link between …
respiratory disease and other adverse outcomes. Epigenetics is a suggested link between …