Although breast cancer stem cells (BCSCs) display plasticity transitioning between quiescent
mesenchymal-like (M) and proliferative epithelial-like (E) states, how this plasticity is …

Background Mitochondrial dynamics underlies malignant transformation, cancer progression,
and response to treatment. Current research presents conflicting evidence for functions of …

Patients with estrogen receptor-positive (ER+) breast cancer, the most common subtype,
remain at risk for lethal metastatic disease years after diagnosis. Recurrence arises partly …

… Buschhaus, Yu-Chih Chen, Henry R. Haley, Tonela Qyli, Benjamin Chiang, Nathan Shen,
Shrila Rajendran, Alyssa Cutter, Yu-Heng Cheng, Yu-Ting Chen, Jason Cong, Phillip C. …

Estrogen receptor-positive (ER+) breast cancer can recur up to 20 years after initial diagnosis.
Delayed recurrences arise from disseminated tumors cells (DTCs) in sites such as bone …

Patients with triple-negative breast cancer remain at risk for metastatic disease despite
treatment. The acquisition of chemoresistance is a major cause of tumor relapse and death, but …

The chemokine receptor CXCR4 regulates fundamental processes in development, normal
physiology, and diseases, including cancer. Small subpopulations of CXCR4-positive cells …

Histopathology, the standard method to assess BM in hematologic malignancies such as
myeloproliferative neoplasms (MPNs), suffers from notable limitations in both research and …

The peritumoral stroma is a complex 3D tissue that provides cells with myriad biophysical
and biochemical cues. Histologic observations suggest that during metastatic spread of …

Mitochondria produce reactive oxygen species (ROS), which function in signal transduction.
Mitochondrial dynamics, encompassing morphological shifts between fission and fusion, …