Introduction This study aimed to determine the homing potential and fate of epidermal neural
crest stem cells (eNCSCs) derived from hair follicles, and bone marrow-derived stem cells (…

Synapse loss is a key feature of dementia, but it is unclear whether synaptic dysfunction
precedes degenerative phases of the disease. Here, we show that even before any decrease in …

Brain perfusion and blood-brain barrier (BBB) integrity are reduced early in Alzheimer’s
disease (AD). We performed single nucleus RNA sequencing of vascular cells isolated from AD …

The early stages of Alzheimer’s disease (AD) have been linked to microcircuit dysfunction
and pathophysiological neuronal firing in several brain regions. Inhibitory GABAergic …

We have previously shown that following severe brain insults, chronic inflammation induced
by lipopolysaccharide (LPS) injection, and status epilepticus, new dentate granule cells …

Lipids play crucial roles in the susceptibility and brain cellular responses to Alzheimer's disease
(AD) and are increasingly considered potential soluble biomarkers in cerebrospinal fluid …

Alzheimer’s disease (AD)-associated synaptic dysfunction drives the progression of pathology
from its earliest stages. Amyloid β (Aβ) species, both soluble and in plaque deposits, have …

Purpose The purpose of the study is to track iron-oxide nanoparticle-labelled adult rat bone
marrow-derived stem cells (IO-rBMSCs) by magnetic resonance imaging (MRI) and …

Neurodegeneration driven by aberrant tau is a key feature of many dementias. Pathological
stages of tauopathy are characterised by reduced synapse density and altered synapse …

Coding variants in the microglial TREM2 ectodomain differentially (R47H> R62H) increase
the risk of Alzheimer’s disease (AD). To define mechanisms responsible, we characterised …