[HTML][HTML] Fast DNA-PAINT imaging using a deep neural network
KK Narayanasamy, JV Rahm, S Tourani… - Nature …, 2022 - nature.com
DNA points accumulation for imaging in nanoscale topography (DNA-PAINT) is a super-resolution
technique with relatively easy-to-implement multi-target imaging. However, image …
technique with relatively easy-to-implement multi-target imaging. However, image …
[HTML][HTML] Diffusion state transitions in single-particle trajectories of MET receptor tyrosine kinase measured in live cells
JV Rahm, S Malkusch, U Endesfelder… - Frontiers in Computer …, 2021 - frontiersin.org
Single-particle tracking enables the analysis of the dynamics of biomolecules in living cells
with nanometer spatial and millisecond temporal resolution. This technique reports on the …
with nanometer spatial and millisecond temporal resolution. This technique reports on the …
[PDF][PDF] CRISPR/Cas12a-mediated labeling of MET receptor enables quantitative single-molecule imaging of endogenous protein organization and dynamics
…, MLIE Harwardt, P Freund, M Meurer, JV Rahm… - Iscience, 2021 - cell.com
Single-molecule localization microscopy (SMLM) reports on protein organization in cells with
near-molecular resolution and in combination with stoichiometric labeling enables protein …
near-molecular resolution and in combination with stoichiometric labeling enables protein …
[HTML][HTML] Biased activation of the receptor tyrosine kinase HER2
C Catapano, JV Rahm, M Omer, L Teodori… - Cellular and molecular …, 2023 - Springer
HER2 belongs to the ErbB sub-family of receptor tyrosine kinases and regulates cellular
proliferation and growth. Different from other ErbB receptors, HER2 has no known ligand. …
proliferation and growth. Different from other ErbB receptors, HER2 has no known ligand. …
Imaging the fibroblast growth factor receptor network on the plasma membrane with DNA-assisted single-molecule super-resolution microscopy
MS Schröder, MLIE Harwardt, JV Rahm, Y Li, P Freund… - Methods, 2021 - Elsevier
Fibroblast growth factor receptors (FGFRs) are a subfamily of receptor tyrosine kinases and
central players in health and disease. Following ligand binding and the formation of homo- …
central players in health and disease. Following ligand binding and the formation of homo- …
[PDF][PDF] Neural network-assisted single-molecule localization microscopy with a weak-affinity protein tag
Single-molecule localization microscopy achieves nanometer spatial resolution by
localizing single fluorophores separated in space and time. A major challenge of single-molecule …
localizing single fluorophores separated in space and time. A major challenge of single-molecule …
Receptor tyrosine kinase MET ligand-interaction classified via machine learning from single-particle tracking data
S Malkusch, JV Rahm, MS Dietz… - Molecular Biology of …, 2022 - Am Soc Cell Biol
Internalin B–mediated activation of the membrane-bound receptor tyrosine kinase MET is
accompanied by a change in receptor mobility. Conversely, it should be possible to infer from …
accompanied by a change in receptor mobility. Conversely, it should be possible to infer from …
The molecular architecture of the kidney slit diaphragm
AN Birtasu, K Wieland, UH Ermel, JV Rahm… - bioRxiv, 2023 - biorxiv.org
Vertebrate life depends on renal function to filter excess fluid and remove low- molecular-weight
waste products. An essential component of the kidney filtration barrier is the slit …
waste products. An essential component of the kidney filtration barrier is the slit …
Extraction of diffusion state transitions in single-particle tracking data of membrane receptors
JV Rahm, S Malkusch, U Endesfelder… - Single Molecule …, 2022 - spiedigitallibrary.org
Single-particle tracking reports on the mobility of biomolecules in living cells with high spatial
and temporal resolution. From single-particle trajectories, information such as the diffusion …
and temporal resolution. From single-particle trajectories, information such as the diffusion …
[PDF][PDF] Multi-target and fast DNA-paint imaging of neuronal tissue using exchange paint and artificial neural networks
The dense nanoscale morphology and arrangement of proteins within the synapse of neuronal
tissue was difficult to visualize until the development of superresolution microscopy. Here…
tissue was difficult to visualize until the development of superresolution microscopy. Here…