User profiles for Johanne Marie Justesen
Johanne Marie JustesenBiomedical Data Science, Stanford Medicine Verified email at sund.ku.dk Cited by 4343 |
[HTML][HTML] Genome-wide physical activity interactions in adiposity―A meta-analysis of 200,452 adults
Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity.
To identify adiposity loci whose effects are modified by PA, we performed genome-wide …
To identify adiposity loci whose effects are modified by PA, we performed genome-wide …
[HTML][HTML] Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
…, JE Huffman, AU Jackson, JM Justesen… - Nature …, 2017 - nature.com
Few genome-wide association studies (GWAS) account for environmental exposures, like
smoking, potentially impacting the overall trait variance when investigating the genetic …
smoking, potentially impacting the overall trait variance when investigating the genetic …
[PDF][PDF] Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation
Epidemiological studies reveal that marijuana increases the risk of cardiovascular disease (CVD);
however, little is known about the mechanism. Δ 9 -tetrahydrocannabinol (Δ 9 -THC), …
however, little is known about the mechanism. Δ 9 -tetrahydrocannabinol (Δ 9 -THC), …
[HTML][HTML] Significant sparse polygenic risk scores across 813 traits in UK Biobank
We present a systematic assessment of polygenic risk score (PRS) prediction across more
than 1,500 traits using genetic and phenotype data in the UK Biobank. We report 813 sparse …
than 1,500 traits using genetic and phenotype data in the UK Biobank. We report 813 sparse …
[HTML][HTML] Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 …
Genome wide association studies (GWAS) for fasting glucose (FG) and insulin (FI) have
identified common variant signals which explain 4.8% and 1.2% of trait variance, respectively. It …
identified common variant signals which explain 4.8% and 1.2% of trait variance, respectively. It …
[HTML][HTML] A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
…, P Jousilahti, A Jula, J Marie Justesen… - Nature …, 2016 - nature.com
Large consortia have revealed hundreds of genetic loci associated with anthropometric traits,
one trait at a time. We examined whether genetic variants affect body shape as a …
one trait at a time. We examined whether genetic variants affect body shape as a …
SGLT2 inhibitor ameliorates endothelial dysfunction associated with the common ALDH2 alcohol flushing variant
The common aldehyde dehydrogenase 2 (ALDH2) alcohol flushing variant known as
ALDH2*2 affects ∼8% of the world’s population. Even in heterozygous carriers, this missense …
ALDH2*2 affects ∼8% of the world’s population. Even in heterozygous carriers, this missense …
[HTML][HTML] Studies of the association of Arg72Pro of tumor suppressor protein p53 with type 2 diabetes in a combined analysis of 55,521 Europeans
KS Burgdorf, N Grarup, JM Justesen, MN Harder… - PLoS one, 2011 - journals.plos.org
Aims A study of 222 candidate genes in type 2 diabetes reported association of variants in
RAPGEF1, ENPP1, TP53, NRF1, SLC2A2, SLC2A4 and FOXC2 with type 2 diabetes in 4,805 …
RAPGEF1, ENPP1, TP53, NRF1, SLC2A2, SLC2A4 and FOXC2 with type 2 diabetes in 4,805 …
A genetic risk score of 45 coronary artery disease risk variants associates with increased risk of myocardial infarction in 6041 Danish individuals
…, A Borglykke, KH Allin, CH Sandholt, JM Justesen… - Atherosclerosis, 2015 - Elsevier
Background In Europeans, 45 genetic risk variants for coronary artery disease (CAD) have
been identified in genome-wide association studies. We constructed a genetic risk score (…
been identified in genome-wide association studies. We constructed a genetic risk score (…
A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk
To identify novel coding association signals and facilitate characterization of mechanisms
influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived …
influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived …