Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity.
To identify adiposity loci whose effects are modified by PA, we performed genome-wide …

Few genome-wide association studies (GWAS) account for environmental exposures, like
smoking, potentially impacting the overall trait variance when investigating the genetic …

Epidemiological studies reveal that marijuana increases the risk of cardiovascular disease (CVD);
however, little is known about the mechanism. Δ 9 -tetrahydrocannabinol (Δ 9 -THC), …

We present a systematic assessment of polygenic risk score (PRS) prediction across more
than 1,500 traits using genetic and phenotype data in the UK Biobank. We report 813 sparse …

Genome wide association studies (GWAS) for fasting glucose (FG) and insulin (FI) have
identified common variant signals which explain 4.8% and 1.2% of trait variance, respectively. It …

Large consortia have revealed hundreds of genetic loci associated with anthropometric traits,
one trait at a time. We examined whether genetic variants affect body shape as a …

The common aldehyde dehydrogenase 2 (ALDH2) alcohol flushing variant known as
ALDH2*2 affects ∼8% of the world’s population. Even in heterozygous carriers, this missense …

Aims A study of 222 candidate genes in type 2 diabetes reported association of variants in
RAPGEF1, ENPP1, TP53, NRF1, SLC2A2, SLC2A4 and FOXC2 with type 2 diabetes in 4,805 …

Background In Europeans, 45 genetic risk variants for coronary artery disease (CAD) have
been identified in genome-wide association studies. We constructed a genetic risk score (…

To identify novel coding association signals and facilitate characterization of mechanisms
influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived …