… Abdel-Haq wrote the manuscript with support from JCM Schlachetzki. JCM Schlachetzki
and CK Glass critically reviewed and edited the manuscript. SK Mazmanian contributed to the …

Oligodendrocytes, the myelinating cells of the central nervous system, mediate rapid action
potential conduction and provide trophic support for axonal as well as neuronal maintenance…

INTRODUCTION Microglia play essential roles in central nervous system homeostasis and
influence diverse aspects of neuronal function, including refinement of synaptic networks and …

Noncoding genetic variation is a major driver of phenotypic diversity, but functional interpretation
is challenging. To better understand common genetic variation associated with brain …

Background Frontotemporal dementia (FTD) is a complex disorder characterised by a broad
range of clinical manifestations, differential pathological signatures, and genetic variability. …

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by erosive polyarthritis.
Beyond joint pathology, RA is associated with neuropsychiatric comorbidity including …

Sporadic Alzheimer's disease (AD) exclusively affects elderly people. Using direct
conversion of AD patient fibroblasts into induced neurons (iNs), we generated an age-equivalent …

Tissue environment plays a powerful role in establishing and maintaining the distinct
phenotypes of resident macrophages, but the underlying molecular mechanisms remain poorly …

Distinct gait characteristics like short steps and shuffling gait are prototypical signs commonly
observed in Parkinson’s disease. Routinely assessed by observation through clinicians, …

The drivers of sporadic Alzheimer's disease (AD) remain incompletely understood. Utilizing
directly converted induced neurons (iNs) from AD-patient-derived fibroblasts, we identified a …