While CaMKII has long been known to be essential for synaptic plasticity and learning, recent
work points to new dimensions of CaMKII function in the nervous system, revealing that …

This review addresses the localized regulation of voltage-gated ion channels by
phosphorylation. Comprehensive data on channel regulation by associated protein kinases, …

The existence of a large number of receptors coupled to heterotrimeric guanine nucleotide
binding proteins (G proteins) raises the question of how a particular receptor selectively …

L-type Ca 2+ channels play a critical role in regulating Ca 2+ -dependent signaling in cardiac
myocytes, including excitation-contraction coupling; however, the subcellular localization …

Voltage-dependent L-type Ca 2+ channels are multisubunit transmembrane proteins, which
allow the influx of Ca 2+ (I Ca ) essential for normal excitability and excitation-contraction …

Calcium–calmodulin (CaM)-dependent protein kinase II (CaMKII) is the most abundant
protein in excitatory synapses and is central to synaptic plasticity, learning and memory. It is …

The establishment of neural circuitry requires vast numbers of synapses to be generated
during a specific window of brain development, but it is not known why the developing …

To identify and localize the protein products of genes encoding distinct L-type calcium channels
in central neurons, anti-peptide antibodies specific for the class C and class D alpha 1 …

Calcium- and calmodulin-dependent protein kinase II (CaMKII) and glutamate receptors are
integrally involved in forms of synaptic plasticity that may underlie learning and memory. In …

A site-directed anti-peptide antibody (anti-CNA1) directed against the alpha 1 subunit of
class A calcium channels (alpha 1A) recognized a protein of approximately 190-200 kDa in …