Integrins are important therapeutic targets. However, current RGD-based anti-integrin drugs
are also partial agonists, inducing conformational changes that trigger potentially fatal …

A prevailing dogma is that inhibition of vascular thrombosis by antagonizing platelet integrin
αIIbβ3 cannot be achieved without compromising hemostasis, thus causing serious …

The integrin αVβ3 receptor has been implicated in several important diseases, but no
antagonists are approved for human therapy. One possible limitation of current small-molecule …

The function-blocking, non-RGD-containing, and primate-specific mouse monoclonal antibody
17E6 binds the αV subfamily of integrins. 17E6 is currently in phase II clinical trials for …

… Johannes van Agthoven performed the structure analysis experiments and revised the
manuscript. Denis Bernot, Marie Loosveld, Céline Falaise, and Pierre Emmanuel Morange …

Targeting both integrins αVβ3 and α5β1 simultaneously appears to be more effective in cancer
therapy than targeting each one alone. The structural requirements for bispecific binding …

The aspartate in the prototypical integrin-binding motif Arg-Gly-Asp binds the integrin βA
domain of the β-subunit through a divalent cation at the metal ion-dependent adhesion site (…

Background. The clinical results of radiotherapy and endoscopic cordectomy for T1a glottic
carcinoma are reported to be similar, but costs of both treatments may differ. Therefore, we …

Integrins αVβ3 and α5β1 play critical roles in tumor survival, invasion, metastasis, and
angiogenesis and are validated targets for cancer therapy and molecular imaging. Increasing …

… (van Agthoven et al. 2011b, 2015). For punctual ion sources such as matrix-assisted laser
desorption ionization (MALDI), the amount of sample consumed only depends on the number …