The AAA+-type ATPase p97 governs an ever-expanding number of cellular processes
reaching from degradation of damaged proteins and organelles to key signaling events and …

The AAA+ ATPase p97 (also called VCP or Cdc48) is a major protein unfolding machine
with hundreds of clients in diverse cellular pathways that are critical for cell homeostasis, …

During DNA double-strand break (DSB) repair, the ring-shaped Ku70/80 complex becomes
trapped on DNA and needs to be actively extracted, but it has remained unclear what …

The AAA+ ATPase p97/VCP together with different sets of substrate-delivery adapters and
accessory cofactor proteins unfolds ubiquitinated substrates to facilitate degradation by the …

The functional diversity of protein phosphatase-1 (PP1), with its countless substrates, relies
on the ordered assembly of alternative PP1 holoenzymes. Here, we show that newly …

All Hedgehog (Hh) proteins are released from producing cells despite being synthesized as
N- and C-terminally lipidated, membrane-tethered molecules. Thus, a cellular mechanism is …

The AAA+‐ATPase p97 (also called VCP or Cdc48) unfolds proteins and disassembles
protein complexes in numerous cellular processes, but how substrate complexes are loaded …

The protease SPRTN degrades DNA-protein crosslinks (DPCs) that threaten genome stability.
SPRTN has been connected to the ubiquitin-directed protein unfoldase p97 (also called …

Activated sulfate in the form of 3′-phosphoadenosine 5′-phosphosulfate (PAPS) is needed
for all sulfation reactions in eukaryotes with implications for the build-up of extracellular …

The high-energy sulfate donor 3′-phosphoadenosine-5′-phosphosulfate (PAPS),
generated by human PAPS synthase isoforms PAPSS1 and PAPSS2, is required for all human …