Type I interferons (IFNs) are important for antiviral and autoimmune responses. Retinoic acid-induced
gene I (RIG-I) and mitochondrial antiviral signaling (MAVS) proteins mediate IFN …

Marine-derived actinomycete bacteria are emerging as a valuable resource for bioactive
natural products encompassing a variety of unique structural classes.[1] In our hands, early …

Drugs that mirror the cellular effects of starvation mimics are considered promising
therapeutics for common metabolic disorders, such as obesity, liver steatosis, and for ageing. …

Diversity in the genetic lesions that cause cancer is extreme. In consequence, a pressing
challenge is the development of drugs that target patient-specific disease mechanisms. To …

10.7554/eLife.03206.001 Retinol plays a vital role in the immune response to infection, yet
proteins that mediate retinol transport during infection have not been identified. Serum …

The structures of lipopeptides lobocyclamides A (1), B (2), and C (3) were solved using a
combination of mass spectrometry, 2D NMR spectroscopy, and degradative analysis. …

The gut-brain axis is crucial to microbial-host interactions. The neurotransmitter serotonin is
primarily synthesized in the gastrointestinal (GI) tract, where it is secreted into the lumen and …

Covering: up to 2018 With contributions from the global natural product (NP) research
community, and continuing the Raw Data Initiative, this review collects a comprehensive …

Hypoxia inducible factors (HIFs) are heterodimeric transcription factors induced in a variety
of pathophysiological settings, including cancer. We describe the first detailed structure–…

Chemical examination of the secondary metabolites of a marine Saccharomonospora sp.,
isolated from marine sediments collected at the mouth of the La Jolla Submarine Canyon, …