β-Sheet-rich α-synuclein (αS) aggregates characterize Parkinson’s disease (PD). αS was
long believed to be a natively unfolded monomer, but recent work suggests it also occurs in α-…

Missense mutations in the multi-domain kinase LRRK2 cause late onset familial Parkinson's
disease. They most commonly with classic proteinopathy in the form of Lewy bodies and …

α‐Synuclein (αSyn) is a key player in the pathogenesis of Parkinson's disease and other
synucleinopathies. Here, we report the existence of a novel soluble α‐helical conformer of αSyn…

Since researchers identified α-synuclein as the principal component of Lewy bodies and
Lewy neurites, studies have suggested that it plays a causative role in the pathogenesis of …

α-Synuclein is a presynaptic protein that regulates synaptic vesicle trafficking under physiological
conditions. However, in several neurodegenerative diseases, including Parkinson’s …

SMOKE abatement is within that class of subjects sometimes designated as' non-controversial',
not because no controversies are involved, but because political parties have no definite …

Corrigendum: Parkinson-causing α-synuclein missense mutations shift native tetramers to
monomers as a mechanism for disease initiation - PMC Back to Top Skip to main content NIH …

Introduction: Parkinson's disease (PD) is a progressive movement disorder characterized by
heterogenous motor dysfunction with fluctuations in severity. Objective, short-timescale …

London, August, 10th, 1836. You have no sooner a guinea in London than you have none.
In addition to the ways and means I pointed out in my last, gather together the letters I wrote …

In both research and diagnostics, immunohistochemistry is an essential method for assessing
pathology in neurodegenerative diseases. Typically, at autopsy, one hemisphere of the …