Actual driving performance and psychomotor function in healthy subjects after acute and subchronic treatment with escitalopram, mirtazapine, and placebo: a …
M Wingen, J Bothmer, S Langer… - Journal of clinical …, 2005 - psychiatrist.com
Objective: The effects of escitalopram 10 to 20 mg/day and mirtazapine 30 to 45 mg/day on
actual driving and psychomotor performance of 18 healthy subjects were determined in a …
actual driving and psychomotor performance of 18 healthy subjects were determined in a …
Respiratory effects of the nociceptin/orphanin FQ peptide and opioid receptor agonist, cebranopadol, in healthy human volunteers
…, J Hay, GJ Groeneveld, M Neukirchen, J Bothmer… - …, 2017 - pubs.asahq.org
Background Cebranopadol is a novel strong analgesic that coactivates the nociceptin/orphanin
FQ receptor and classical opioid receptors. There are indications that activation of the …
FQ receptor and classical opioid receptors. There are indications that activation of the …
[HTML][HTML] Accurate pain reporting training diminishes the placebo response: results from a randomised, double-blind, crossover trial
Analgesic trials frequently fail to demonstrate efficacy of drugs known to be efficacious. Poor
pain reporting accuracy is a possible source for this low essay-sensitivity. We report the …
pain reporting accuracy is a possible source for this low essay-sensitivity. We report the …
[PDF][PDF] Cebranopadol: a novel, first-in-class, strong analgesic: results from a randomized phase IIa clinical trial in postoperative acute pain
A Scholz, J Bothmer, M Kok, K Hoschen… - Pain physician, 2018 - researchgate.net
Background: Cebranopadol is a potent, first-in-class analgesic with a novel mechanistic
approach combining nociceptin/orphanin FQ peptide (NOP) and opioid peptide receptor …
approach combining nociceptin/orphanin FQ peptide (NOP) and opioid peptide receptor …
Affected enzyme activities in Alzheimer's disease are sensitive to antemortem hypoxia
D Terwel, J Bothmer, E Wolf, F Meng, J Jolles - Journal of the neurological …, 1998 - Elsevier
Many enzyme activities in Alzheimer's disease (AD) are changed. Some of these enzyme
activities are related to certain neurotransmitter systems. Enzymes in the brain can also be …
activities are related to certain neurotransmitter systems. Enzymes in the brain can also be …
[HTML][HTML] Human Mitragynine and 7-Hydroxymitragynine Pharmacokinetics after Single and Multiple Daily Doses of Oral Encapsulated Dried Kratom Leaf Powder
MA Huestis, MA Brett, J Bothmer, R Atallah - Molecules, 2024 - mdpi.com
Kratom leaves, consumed by millions worldwide as tea or ground leaf powder, contain
multiple alkaloids, with mitragynine being the most abundant and responsible for most effects. …
multiple alkaloids, with mitragynine being the most abundant and responsible for most effects. …
Behavioural and biochemical effects of acute central metabolic inhibition: effects of acetyl-L-carnitine
A Blokland, J Bothmer, W Honig, J Jolles - European journal of …, 1993 - Elsevier
In the present study we evaluated a new method to assess the behavioural and biochemical
effects of a brief period of acute hypoxia in the brain. In this method, cyanide is injected into …
effects of a brief period of acute hypoxia in the brain. In this method, cyanide is injected into …
Phosphoinositide metabolism, aging and Alzheimer's disease
J Bothmer, J Jolles - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 1994 - Elsevier
In aging and age-associated disorders like Alzheimer's disease, the performance of various
brain functions declines. A disturbance in signal transduction between brain cells could …
brain functions declines. A disturbance in signal transduction between brain cells could …
[HTML][HTML] Genome-wide association study of pain sensitivity assessed by questionnaire and the cold pressor test
P Fontanillas, A Kless, J Bothmer, JY Tung… - Pain, 2022 - journals.lww.com
We deployed an online pain sensitivity questionnaire (PSQ) and an at-home version of the
cold pressor test (CPT) in a large genotyped cohort. We performed genome-wide association …
cold pressor test (CPT) in a large genotyped cohort. We performed genome-wide association …
Phosphoinositide kinase activities in synaptosomes prepared from brains of patients with Alzheimer's disease and controls
J Bothmer, M Markerink, J Jolles - Neuroscience letters, 1994 - Elsevier
Previously, phosphatidylinositol (PI) kinase activity in cytosolic fractions repared from
postmortem tissue of the cerebral cortex from patients with Alzheimer's disease (AD) appeared to …
postmortem tissue of the cerebral cortex from patients with Alzheimer's disease (AD) appeared to …