Eukaryotic cells respond to unfolded proteins in their endoplasmic reticulum (ER stress), amino
acid starvation, or oxidants by phosphorylating the α subunit of translation initiation factor …

Interferons are circulating factors that bind to cell surface receptors, activating a signaling
cascade, ultimately leading to both an antiviral response and an induction of growth inhibitory …

Recent clinical data have emphatically shown the capacity of our immune systems to eradicate
even advanced cancers. Although oncolytic viruses (OVs) were originally designed to …

To effectively build on the recent successes of immune checkpoint blockade, adoptive T cell
therapy and cancer vaccines, it is critical to rationally design combination strategies that will …

Oncolytic viruses and active immunotherapeutics have complementary mechanisms of action
(MOA) that are both self amplifying in tumors, yet the impact of dose on subject outcome is …

In the past 5 years, the field of oncolytic virus research has matured significantly and is moving
past the stage of being a laboratory novelty into a new era of preclinical and clinical trials. …

Oncolytic virotherapy is an emerging treatment modality that uses replication-competent
viruses to destroy cancers. Recent advances include preclinical proof of feasibility for a single-…

The interferon-inducible, double-stranded RNA-dependent protein kinase PKR has been
implicated in anti-viral, anti-tumor, and apoptotic responses. Others have attempted to examine …

T HE interaction of cells with the extracellular matrix regulates cell shape, motility, growth,
survival, differentiation and gene expression, through integrin-mediated signal transduction 1–…

Ideally, an oncolytic virus will replicate preferentially in malignant cells, have the ability to
treat disseminated metastases, and ultimately be cleared by the patient. Here we present …