Strains of mice that show characteristic patterns of behavior are critical for research in
neurobehavioral genetics. Possible confounding influences of the laboratory environment were …

Choosing the best genetic strains of mice for developing a new knockout or transgenic
mouse requires extensive knowledge of the endogenous traits of inbred strains. Background …

Because of intrinsic differences between humans and mice, no single mouse model can
represent all features of a complex human trait such as alcoholism. It is therefore necessary to …

To determine genetic differences in ethanol consumption, 15 commonly used inbred strains
of mice were given ad libitum two-bottle choice between ethanol, 0.2% saccharin, or ethanol …

It is sometimes supposed that standardizing tests of mouse behavior will ensure similar
results in different laboratories. We evaluated this supposition by conducting behavioral tests …

The role of withdrawal‐related phenomena in the development and maintenance of alcohol
addiction remains under debate. A ‘self‐medication’ framework postulates that emotional …

Much evidence from studies in humans and animals supports the hypothesis that alcohol
addiction is a complex disease with both hereditary and environmental influences. Molecular …

Behavioral and pharmacological responses of selectively bred and inbred rodent lines have
been analyzed to elucidate many features of drug sensitivity and the adverse effects of drugs…

Substantial evidence links alcohol drinking and serotonin (5-HT) functioning in animals 1 .
Lowered central 5-HT neurotransmission has been found in a subgroup of alcoholics, …

Inbred strains are genetically stable across time and laboratories, allowing scientists to
accumulate a record of phenotypes, including physiological characteristics and behaviors. To …