Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

VM Van Deerlin, PMA Sleiman, M Martinez-Lage… - Nature …, 2010 - nature.com
Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile
dementia. The predominant neuropathology is FTLD with TAR DNA-binding protein (TDP-43) …

Aging increases cell-to-cell transcriptional variability upon immune stimulation

CP Martinez-Jimenez, N Eling, HC Chen, CA Vallejos… - Science, 2017 - science.org
Aging is characterized by progressive loss of physiological and cellular functions, but the
molecular basis of this decline remains unclear. We explored how aging affects transcriptional …

Identification of 53 compounds that block Ebola virus-like particle entry via a repurposing screen of approved drugs

…, W Sun, C Martínez-Romero… - Emerging microbes & …, 2014 - Taylor & Francis
In light of the current outbreak of Ebola virus disease, there is an urgent need to develop
effective therapeutics to treat Ebola infection, and drug repurposing screening is a potentially …

[HTML][HTML] Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis

C Ernst, N Eling, CP Martinez-Jimenez… - Nature …, 2019 - nature.com
Male gametes are generated through a specialised differentiation pathway involving a series
of developmental transitions that are poorly characterised at the molecular level. Here, we …

Evaluation of the pediatric craniocervical junction on MDCT

…, CA Rojas, CR Martinez - American Journal of …, 2009 - Am Roentgen Ray Soc
OBJECTIVE. The purpose of our study was to establish normal values on MDCT images for
the measurement of various craniocervical junction relationships in children and to address …

CT of the pulmonary nodule: a cooperative study.

…, AV Proto, JR Muhm, JW Walsh, CR Martinez… - Radiology, 1986 - pubs.rsna.org
To evaluate the role of computed tomography (CT) in the investigation of pulmonary nodules,
a special reference phantom that enabled CT densitometric measurements independent of …

[HTML][HTML] Divergent dynamics and the Kauzmann temperature in glass forming systems

JC Martinez-Garcia, SJ Rzoska, A Drzozd-Rzoska… - Scientific reports, 2014 - nature.com
In the last decade the challenging analysis of previtreous behavior of relaxation time (τ(T))
in ultraviscous low molecular weight liquids led to the conceptual shift of the glass transition …

IL‐7‐dependent compositional changes within the γδ T cell pool in lymph nodes during ageing lead to an unbalanced anti‐tumour response

HC Chen, N Eling, CP Martinez‐Jimenez… - EMBO …, 2019 - embopress.org
How the age‐associated decline of immune function leads to increased cancer incidence is
poorly understood. Here, we have characterised the cellular composition of the γδ T‐cell …

[HTML][HTML] Fragility and basic process energies in vitrifying systems

JC Martinez-Garcia, SJ Rzoska, A Drozd-Rzoska… - Scientific reports, 2015 - nature.com
The concept of ‘fragility’ constitutes a central point of the glass transition science serving as
the ‘universal’ metric linking previtreous dynamics of qualitatively distinct systems. Finding …

Use of a β-hCG discriminatory zone with bedside pelvic ultrasonography

…, HH West, D Ravikumar, C Martinez… - Annals of emergency …, 2011 - Elsevier
STUDY OBJECTIVE: We seek to assess the performance of the β human chorionic
gonadotropin (β-hCG) “discriminatory zone” when using bedside pelvic ultrasonography in the …