Mycobacterium tuberculosis claims more human lives each year than any other bacterial
pathogen. Infection is maintained in spite of acquired immunity and resists eradication by …

Interferon-γ (IFN-γ) provides an essential component of immunity to tuberculosis by activating
infected host macrophages to directly inhibit the replication of Mycobacterium tuberculosis (…

Genes involved in fatty acid catabolism have undergone extensive duplication in the genus
Mycobacterium, which includes the etiologic agents of leprosy and tuberculosis. Here, we …

New drugs are required to counter the tuberculosis (TB) pandemic. Here, we describe the
synthesis and characterization of 1,3-benzothiazin-4-ones (BTZs), a new class of …

The success of Mycobacterium tuberculosis as a pathogen is largely attributable to its ability
to persist in host tissues, where drugs that are rapidly bactericidal in vitro require prolonged …

Exposure of an isogenic bacterial population to a cidal antibiotic typically fails to eliminate a
small fraction of refractory cells. Historically, fractional killing has been attributed to …

Reactive nitrogen species (RNS) play an essential role in host defence against Mycobacterium
tuberculosis (MTB) in the mouse model of tuberculosis (TB), as evidenced by the …

Phenotypic heterogeneity, defined as metastable variation in cellular parameters generated
by epigenetic mechanisms, is crucial for the persistence of bacterial populations under …

Growth of bacteria and fungi on fatty acid substrates requires the catabolic β‐oxidation cycle
and the anaplerotic glyoxylate cycle. Propionyl‐CoA generated by β‐oxidation of odd‐chain …

Isocitrate lyase (ICL) plays a pivotal role in the persistence of Mycobacterium tuberculosis in
mice by sustaining intracellular infection in inflammatory macrophages. The enzyme allows …