User profiles for John D. Tompkins
 | John D. TompkinsUniversity of California Los Angeles Verified email at mednet.ucla.edu Cited by 1055 |
Systemic AAV vectors for widespread and targeted gene delivery in rodents
We recently developed adeno-associated virus (AAV) capsids to facilitate efficient and
noninvasive gene transfer to the central and peripheral nervous systems. However, a detailed …
noninvasive gene transfer to the central and peripheral nervous systems. However, a detailed …
[HTML][HTML] Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies
Heart rate is under the precise control of the autonomic nervous system. However, the wiring
of peripheral neural circuits that regulate heart rate is poorly understood. Here, we develop …
of peripheral neural circuits that regulate heart rate is poorly understood. Here, we develop …
Innervation and neuronal control of the mammalian sinoatrial node a comprehensive atlas
…, J Schwaber, RL Lux, I Efimov, JD Tompkins… - Circulation …, 2021 - Am Heart Assoc
Rationale: Cardiac function is under exquisite intrinsic cardiac neural control. Neuroablative
techniques to modulate control of cardiac function are currently being studied in patients, …
techniques to modulate control of cardiac function are currently being studied in patients, …
Neuroscientific therapies for atrial fibrillation
…, S Stavrakis, C Meyer, JD Tompkins… - Cardiovascular …, 2021 - academic.oup.com
The cardiac autonomic nervous system (ANS) plays an integral role in normal cardiac
physiology as well as in disease states that cause cardiac arrhythmias. The cardiac ANS, …
physiology as well as in disease states that cause cardiac arrhythmias. The cardiac ANS, …
Increased arrhythmia susceptibility in type 2 diabetic mice related to dysregulation of ventricular sympathetic innervation
…, C Meyer, JL Ardell, JD Tompkins - American Journal …, 2019 - journals.physiology.org
Patients with type 2 diabetes mellitus (T2DM) have a greater risk of developing life-threatening
cardiac arrhythmias. Because the underlying mechanisms and potential influence of …
cardiac arrhythmias. Because the underlying mechanisms and potential influence of …
Neurally released pituitary adenylate cyclase‐activating polypeptide enhances guinea pig intrinsic cardiac neurone excitability
Intracellular recordings were made in vitro from guinea‐pig cardiac ganglia to determine
whether endogenous neuropeptides such as pituitary adenylate cyclase‐activating polypeptide …
whether endogenous neuropeptides such as pituitary adenylate cyclase‐activating polypeptide …
Activation of MEK/ERK signaling contributes to the PACAP-induced increase in guinea pig cardiac neuron excitability
JD Tompkins, TA Clason… - … of Physiology-Cell …, 2016 - journals.physiology.org
Pituitary adenylate cyclase (PAC)-activating polypeptide (PACAP) peptides (Adcyap1)
signaling at the selective PAC1 receptor (Adcyap1r1) participate in multiple homeostatic and …
signaling at the selective PAC1 receptor (Adcyap1r1) participate in multiple homeostatic and …
Effects of CYP-induced cystitis on PACAP/VIP and receptor expression in micturition pathways and bladder function in mice with overexpression of NGF in urothelium
BM Girard, JD Tompkins, RL Parsons, V May… - Journal of Molecular …, 2012 - Springer
We have previously demonstrated nerve growth factor (NGF) regulation of pituitary adenylate
cyclase-activating polypeptide (PACAP)/receptors in bladder reflex pathways using a …
cyclase-activating polypeptide (PACAP)/receptors in bladder reflex pathways using a …
Nickel suppresses the PACAP-induced increase in guinea pig cardiac neuron excitability
JD Tompkins, LA Merriam, BM Girard… - … of Physiology-Cell …, 2015 - journals.physiology.org
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a potent intercellular signaling
molecule involved in multiple homeostatic functions. PACAP/PAC 1 receptor signaling …
molecule involved in multiple homeostatic functions. PACAP/PAC 1 receptor signaling …
Enhancement of Ih, but not inhibition of IM, is a key mechanism underlying the PACAP-induced increase in excitability of guinea pig intrinsic cardiac neurons
JD Tompkins, YT Lawrence… - American Journal of …, 2009 - journals.physiology.org
Pituitary adenylate cyclase-activating polypeptide (PACAP) increases excitability of guinea
pig cardiac neurons, an effect mediated by PACAP-selective PAC 1 receptors. In dissociated …
pig cardiac neurons, an effect mediated by PACAP-selective PAC 1 receptors. In dissociated …