The C-terminal CAAX motif of the yeast mating factors is modified by proteolysis to remove
the three terminal amino acids (-AAX) leaving a C-terminal cysteine resi-, due that is …

Ras signalling has classically been thought to occur exclusively at the inner surface of a
relatively uniform plasma membrane. Recent studies have shown that Ras proteins interact …

The small guanine nucleotide binding protein Ras participates in a growth promoting signal
transduction pathway. The mechanism by which interaction of Ras with the protein kinase …

The hypothesis that lipid rafts exist in plasma membranes and have crucial biological functions
remains controversial. The lateral heterogeneity of proteins in the plasma membrane is …

The C-terminal CAAX motif of fas proteins undergoes a triplet of posttranslational modifications
that are required for membrane association. The CAAX motif lies immediately C-terminal …

Localization of signaling complexes to specific microdomains coordinates signal transduction
at the plasma membrane. Using immunogold electron microscopy of plasma membrane …

Caveolae are abundant cell-surface organelles involved in lipid regulation and endocytosis.
We used comparative proteomics to identify PTRF (also called Cav-p60, Cavin) as a …

Although we have amassed extensive catalogues of signalling network components, our
understanding of the spatiotemporal control of emergent network structures has lagged behind. …

Different sites of plasma membrane attachment may underlie functional differences between
isoforms of Ras. Here we show that palmitoylation and farnesylation targets H-ras to lipid …

Ha-, N-, and Ki-Ras are ubiquitously expressed in mammalian cells and can all interact with
the same set of effector proteins. We show here, however, that in vivo there are marked …