Eukaryotic genomes are replicated from large numbers of replication origins distributed on
multiple chromosomes. The activity of these origins must be coordinated so that the entire …

DNA replication must be tightly regulated to ensure that the genome is accurately duplicated
during each cell cycle. When these regulatory mechanisms fail, replicative stress and DNA …

DNA replication in eukaryotic cells initiates from large numbers of sites called replication
origins. Initiation of replication from these origins must be tightly controlled to ensure the entire …

Little is known about the DNA helicases required for the elongation phase of eukaryotic
chromosome replication. Minichromosome maintenance (MCM) protein complexes have DNA …

DNA replication in eukaryotic cells initiates from many replication origins 1 which fire throughout
the S phase of the cell cycle in a predictable pattern: some origins fire early, others late …

The checkpoint kinase proteins Mec1 and Rad53 are required in the budding yeast,
Saccharomyces cerevisiae, to maintain cell viability in the presence of drugs causing damage to …

The licensing of eukaryotic DNA replication origins, which ensures once-per-cell-cycle
replication, involves the loading of six related minichromosome maintenance proteins (Mcm2–7) …

The integration of chromosomal DNA replication into the eukaryotic cell cycle might involve
temporal regulation of interactions between cellular factors and replication origins. We show …

The Cdc6 protein is essential for the assembly of pre-replicative complexes (pre-RCs) at
origins of DNA replication in the budding yeast Saccharomyces cerevisiae. This reaction is …

Cells experiencing DNA replication stress activate a response pathway that delays entry into
mitosis and promotes DNA repair and completion of DNA replication. The protein kinases …