BACKGROUND Rupture of atherosclerotic plaques is probably the most important mechanism
underlying the sudden onset of acute coronary syndromes. Macrophages may release …

Arterial thrombosis is considered to arise from the interaction of tissue factor (TF) in the
vascular wall with platelets and coagulation factors in circulating blood. According to this …

Ci/Gli zinc finger proteins mediate the transcriptional effects of Hedgehog protein signals. In
Drosophila, Ci action as transcriptional repressor or activator is contingent upon Hedgehog-…

Background Rupture of the fibrous cap of the atherosclerotic plaque is a key event that
predisposes to coronary thrombosis, leading to acute coronary syndromes. Recent studies have …

Background The thrombogenicity of a disrupted atherosclerotic lesion is dependent on the
nature and extent of the plaque components exposed to flowing blood together with local …

We studied the clinical features and course (average follow-up time, 18 months) of 27 patients
with acute dilated cardiomyopathy (symptoms for less than 6 months) who were referred …

The Association for European Cardiovascular Pathology and the Society for Cardiovascular
Pathology have produced this position paper concerning the current role of endomyocardial …

Background—High-resolution MRI has the potential to noninvasively image the human
coronary artery wall and define the degree and nature of coronary artery disease. Coronary …

Most current models propose Sonic hedgehog (Shh) as the primary determinant of
anteroposterior development of amniote limbs 1 . Shh protein is said to be required to direct the …

Background—Lipid-rich, inflamed atherosclerotic lesions are associated with plaque rupture
and thrombosis, which are the most important causes of death in patients with diabetes …