Histone deacetylase inhibitors (HDACi) are in clinical trials against a variety of cancers.
Despite early successes, results against the more common solid tumors have been mixed. How …

Pheromone signaling plays an essential role in the mating and sexual development of
mushroom fungi. Multiallelic genes encoding the peptide pheromones and their cognate 7-…

Our results indicate that the controlled analysis of RNA-seq data supports earlier conclusions
that the active X chromosome is upregulated in mammals and that adjustment for the …

Histone deacetylase inhibitors (HDACi) are increasingly used as therapeutic agents, but the
mechanisms by which they alter cell behaviour remain unclear. Here we use microarray …

Background The genome-wide hyperacetylation of chromatin caused by histone deacetylase
inhibitors (HDACi) is surprisingly well tolerated by most eukaryotic cells. The homeostatic …

Background Immunolabeling of metaphase chromosome spreads can map components of
the human epigenome at the single cell level. Previously, there has been no systematic …

The behaviour of gas-sensitive resistors based on WO 3 towards small concentrations of ozone
in air can be understood with a simple model involving the reaction of ozone with surface …

The B mating type locus of the basidiomycete Coprinus cinereus encodes a large family of
lipopeptide pheromones and their seven transmembrane domain receptors. Here we show …

Background Histone deacetylase inhibitors (HDACi) cause histone hyperacetylation and
H3K4 hypermethylation in various cell types. They find clinical application as anti-epileptics …

Chromatin configuration influences gene expression in eukaryotes at multiple levels, from
individual nucleosomes to chromatin domains several Mb long. Post-translational …