FMRP loss of function causes Fragile X syndrome (FXS) and autistic features. FMRP is a
polyribosome-associated neuronal RNA-binding protein, suggesting that it plays a key role in …

Protein–RNA interactions have critical roles in all aspects of gene expression. However,
applying biochemical methods to understand such interactions in living tissues has been …

We adapted UV CLIP (cross-linking immunoprecipitation) to accurately locate tens of thousands
of m 6 A residues in mammalian mRNA with single-nucleotide resolution. More than 70…

Understanding the biologic role of N 6 -methyladenosine (m 6 A) RNA modifications in
mRNA requires an understanding of when and where in the life of a pre-mRNA transcript the …

Hepatitis C virus (HCV) uniquely requires the liver-specific microRNA-122 for replication,
yet global effects on endogenous miRNA targets during infection are unexplored. Here, high-…

The SecA adenosine triphosphatase (ATPase) mediates extrusion of the amino termini of
secreted proteins from the eubacterial cytosol based on cycles of reversible binding to the …

microRNAs (miRNAs) act as sequence-specific guides for Argonaute (AGO) proteins, which
mediate posttranscriptional silencing of target messenger RNAs. Despite their importance in …

The control of RNA alternative splicing is critical for generating biological diversity. Despite
emerging genome-wide technologies to study RNA complexity, reliable and comprehensive …

We address the challenge of detecting the contribution of noncoding mutations to disease
with a deep-learning-based framework that predicts the specific regulatory effects and the …

The paraneoplastic neurologic disorders target several families of neuron-specific RNA
binding proteins (RNABPs), revealing that there are unique aspects of gene expression …