Background Carbamazepine causes various forms of hypersensitivity reactions, ranging from
maculopapular exanthema to severe blistering reactions. The HLA-B*1502 allele has been …

A first-year general chemistry course based on constructivist principles and the learning
cycle has been developed. Through the use of cooperative learning techniques, students are …

New technologies and analysis methods are enabling genomic structural variants (SVs) to
be detected with ever-increasing accuracy, resolution and comprehensiveness. To help …

The Alzheimer’s Disease Sequencing Project (ADSP) undertook whole exome sequencing
in 5,740 late-onset Alzheimer disease (AD) cases and 5,096 cognitively normal controls …

Cutaneous leg ulcers are common in sickle cell anaemia and their risk might be genetically
determined. Sickle cell anaemia patients were studied to examine the relationship of leg …

Fetal hemoglobin (HbF) is regulated as a multigenic trait. By genome-wide association study,
we confirmed that HBS1L-MYB intergenic polymorphisms (HMIP) and BCL11A …

In the newly updated 7th Edition, Chemistry: A Guided Inquiry continues to follow the underlying
principles developed by years of extensive research on how students learn, and draws …

New technologies and analysis methods are enabling genomic structural variants (SVs) to
be detected with ever-increasing accuracy, resolution, and comprehensiveness. Translating …

Because regulation of gene expression is heritable and context-dependent, we investigated
AD-related gene expression patterns in cell types in blood and brain. Cis-expression …

Importance Some of the unexplained heritability of Alzheimer disease (AD) may be due to
rare variants whose effects are not captured in genome-wide association studies because …