We provide here a list of 481 P450 genes and 22 pseudogenes, plus all accession numbers
that have been reported as of October 18, 1995. These genes have been described in 85 …

We report the sequence and analysis of the 814-megabase genome of the sea urchin
Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing …

The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of
lobe-finned fish was thought to have become extinct 70 million years ago. The modern …

High levels of polynuclear aromatic hydrocarbon (PAH) carcinogens commonly occur in aquatic
systems where neoplasms arise in fish and other animals. Enzymes that transform PAHs …

Background Increasing use of zebrafish in drug discovery and mechanistic toxicology
demands knowledge of cytochrome P450 (CYP) gene regulation and function. CYP enzymes …

Background: Pollution–unwanted waste released to air, water, and land by human activity–is
the largest environmental cause of disease in the world today. It is responsible for an …

A strong foundation of basic and applied research documents that the estuarine fish Fundulus
heteroclitus and related species are unique laboratory and field models for understanding …

Background: Plastics have conveyed great benefits to humanity and made possible some of
the most significant advances of modern civilization in fields as diverse as medicine, …

In order to use the zebrafish as a model vertebrate to investigate the developmental toxicity
of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), it is essential to know whether one or both …

A procedure to directly measure the cytochrome P-450-dependent 7-ethoxyresorufin O-deethylase
activity with a visible spectrophotometer is described and compared to the standard …