Heterozygous mutations encoding abnormal forms of the death receptor Fas dominantly
interfere with Fas-induced lymphocyte apoptosis in human autoimmune lymphoproliferative …

RNA represents a prominent class of biomolecules. Present in all living systems, RNA plays
many essential roles in gene expression, regulation, and development. Accordingly, many …

Context The World Health Organization system for lymphoma classification relies on histologic
findings from excisional biopsies. In contradistinction to expert guidelines, practitioners …

Antibodies that bind protein antigens are indispensable in biochemical research and modern
medicine. However, knowledge of RNA-binding antibodies and their application in the ever…

Existing evidence suggests that the Varkud satellite (VS) ribozyme accelerates the cleavage
of a specific phosphodiester bond using general acid-base catalysis. The key functionalities …

Phosphorothioate oligonucleotides are indispensable tools for probing nucleic acid structure
and function and for the design of antisense therapeutics. Many applications involving …

Site-bound metal ions participate in the catalytic mechanisms of many ribozymes.
Understanding these mechanisms therefore requires knowledge of the specific ligands on both …

Within the three-dimensional architectures of RNA molecules, divalent metal ions populate
specific locations, shedding their water molecules to form chelates. These interactions help …

Lack of sufficient quantities of isotopically labeled materials has precluded the use of heavy
atom isotope effects to investigate mechanisms of nucleotidyl transfer reactions in nucleic …

Oligoribonucleotides containing a 5′-phosphorothiolate linkage have provided effective
tools to study the mechanisms of RNA catalysis, allowing resolution of kinetic ambiguity …