We systematically generated large-scale data sets to improve genome annotation for the
nematode Caenorhabditis elegans, a key model organism. These data sets include …

RNA interference (RNAi) of target genes is triggered by double-stranded RNAs (dsRNAs)
processed by conserved nucleases and accessory factors. To identify the genetic components …

Three-prime untranslated regions (3′UTRs) of metazoan messenger RNAs (mRNAs) contain
numerous regulatory elements, yet remain largely uncharacterized. Using polyA capture, 3…

Transposable elements (TEs) and DNA repeats are commonly targeted by DNA and histone
methylation to achieve epigenetic gene silencing. We isolated mutations in two Arabidopsis …

Caenorhabditis elegans homologues of the retinoblastoma (Rb) tumour suppressor complex
specify cell lineage during development 1 , 2 . Here we show that mutations in Rb pathway …

We show that miR-1, a conserved muscle-specific microRNA, regulates aspects of both pre-
and postsynaptic function at C. elegans neuromuscular junctions. miR-1 regulates the …

10.7554/eLife.25237.001 The RNA binding protein, LARP1, has been proposed to function
downstream of mTORC1 to regulate the translation of 5’TOP mRNAs such as those encoding …

Endogenous small interfering RNAs (endo-siRNAs) regulate diverse gene expression
programs in eukaryotes by either binding and cleaving mRNA targets or mediating …

Glycolysis is upregulated under conditions such as hypoxia and high energy demand to
promote cell proliferation, although the mechanism remains poorly understood. We find that …

In addition to several hundred microRNAs, C. elegans produces thousands of other small
RNAs targeting coding genes, pseudogenes, transposons, and other noncoding RNAs. Here …