Bone is a complex tissue that provides mechanical support for muscles and joints, protection
for vital organs, a mineral reservoir that is essential for calcium homeostasis, and the …

RANKL is a TNF family member that mediates osteoclast formation, activation, and survival
by activating RANK. The proresorptive effects of RANKL are prevented by binding to its …

There is an unmet need in severe asthma where approximately 40% of patients exhibit poor
β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations. …

Pathways that control, or can be exploited to alter, the increase in airway smooth muscle (ASM)
mass and cellular remodeling that occur in asthma are not well defined. Here we report …

TMEM16A is a Ca 2+ activated Cl − channel with important functions in airways, intestine, and
other epithelial organs. Activation of TMEM16A is proposed as a therapy in cystic fibrosis (…

Asthma is a heterogeneous disease characterized by airway inflammation and hyperreactivity.
IL-17 receptor A (IL-17RA) is a shared receptor subunit required for activity of IL-17 family …

Actomyosin contractility is an essential element of many aspects of cellular biology and
manifests as traction forces that cells exert on their surroundings. The central role of these forces …

Calcium entry into T cells following antigen stimulation is crucial for nuclear factor of
activated T cells (NFAT)–mediated T cell activation. The movement of calcium is mediated by …

To realize the medicinal potential of peptide toxins, naturally occurring disulfide-rich peptides,
as ion channel antagonists, more efficient pharmaceutical optimization technologies must …

Keratinocyte growth factor (KGF or FGF-7) is a member of the heparin binding fibroblast
growth factor (FGF) family and is a paracrine mediator of proliferation and differentiation of a …