ARC1172 is a 41-mer DNA aptamer selected to bind the A1 domain of von Willebrand factor
(VWF). A derivative of ARC1172 with modifications to increase intravascular survival inhibits …

Two molecular sensors that specifically recognize ADP in a background of over 100-fold
molar excess of ATP are described. These sensors are nucleic-acid based and comprise a …

We have utilized in vitro selection technology to develop allosteric ribozyme sensors that
are specific for the small molecule analytes caffeine or aspartame. Caffeine‐ or aspartame‐…

The structure of the bulge-helix-bulge motif that constitutes the intron/exon splice site in H.
volcanii pre-tRNA Trp has been determined by NMR spectroscopy. The conformations of the …

Background: Human genetic variation in the NPR1 (natriuretic peptide receptor 1 gene,
encoding NPR-A, atrial natriuretic peptide receptor 1) was recently shown to affect blood …

Previous studies have shown that SRP19 promotes association of the highly conserved
signal peptide-binding protein, SRP54, with the signal recognition particle (SRP) RNA in both …

… Based on past research findings, and the idea that adequate resources cause positive
moods because they allow one to achieve one's goals (Diener & Fujita, 1995), we hypothesized …

Myers and Diener (1995) asked “Who is happy?” but examined the question of who is more
and who is less happy In fact, most people report a positive level of subjective well-being (…

Fibroblast growth factor (FGF) 21 is a member of the FGF family of proteins. The biological
activity of FGF21 was first shown to induce insulin-independent glucose uptake in adipocytes …

Although the emphasis on positive health by Ryff component of positive psychological
health, although and Singer is commendable, the absence of subjective is not a sufficient …