Stages of pTDP‐43 pathology in amyotrophic lateral sclerosis
…, K Del Tredici, JB Toledo, JL Robinson… - Annals of …, 2013 - Wiley Online Library
Objective To see whether the distribution patterns of phosphorylated 43kDa TAR DNA‐binding
protein (pTDP‐43) intraneuronal inclusions in amyotrophic lateral sclerosis (ALS) permit …
protein (pTDP‐43) intraneuronal inclusions in amyotrophic lateral sclerosis (ALS) permit …
Neuropathologic substrates of Parkinson disease dementia
Objective: A study was undertaken to examine the neuropathological substrates of cognitive
dysfunction and dementia in Parkinson disease (PD). Methods: One hundred forty patients …
dysfunction and dementia in Parkinson disease (PD). Methods: One hundred forty patients …
Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated
… John L Robinson , John L Robinson … Y Lee, John Q Trojanowski, Neurodegenerative
disease concomitant proteinopathies are prevalent, age-related and APOE4-associated, Brain, …
disease concomitant proteinopathies are prevalent, age-related and APOE4-associated, Brain, …
Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies
…, DJ Covell, C Medellin, A Stieber, JL Robinson… - Nature, 2018 - nature.com
In Lewy body diseases—including Parkinson’s disease, without or with dementia, dementia
with Lewy bodies, and Alzheimer’s disease with Lewy body co-pathology 1 —α-synuclein (α-…
with Lewy bodies, and Alzheimer’s disease with Lewy body co-pathology 1 —α-synuclein (α-…
[HTML][HTML] Distribution patterns of tau pathology in progressive supranuclear palsy
…, LD Laat, C Troakes, S Al-Sarraj, JL Robinson… - Acta …, 2020 - Springer
Progressive supranuclear palsy (PSP) is a 4R-tauopathy predominated by subcortical pathology
in neurons, astrocytes, and oligodendroglia associated with various clinical phenotypes…
in neurons, astrocytes, and oligodendroglia associated with various clinical phenotypes…
Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD)
…, M Grossman, JL Robinson, JB Toledo, L Fang… - Acta …, 2014 - Springer
We examined regional distribution patterns of phosphorylated 43-kDa TAR DNA-binding
protein (pTDP-43) intraneuronal inclusions in frontotemporal lobar degeneration (FTLD). …
protein (pTDP-43) intraneuronal inclusions in frontotemporal lobar degeneration (FTLD). …
TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord
…, K Arai, K Del Tredici, JB Toledo, JL Robinson… - Acta …, 2014 - Springer
We examined the phosphorylated 43-kDa TAR DNA-binding protein (pTDP-43) inclusions
as well as neuronal loss in full-length spinal cords and five selected regions of the central …
as well as neuronal loss in full-length spinal cords and five selected regions of the central …
Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion
…, VM Van Deerlin, JL Robinson, L Kwong… - Acta …, 2012 - Springer
C9ORF72-hexanucleotide repeat expansions and ubiquilin-2 (UBQLN2) mutations are
recently identified genetic markers in amyotrophic lateral sclerosis (ALS) and frontotemporal …
recently identified genetic markers in amyotrophic lateral sclerosis (ALS) and frontotemporal …
[PDF][PDF] TDP-43 depletion in microglia promotes amyloid clearance but also induces synapse loss
…, CM Henstridge, A Valeri, M Merlini, JL Robinson… - Neuron, 2017 - cell.com
Microglia coordinate various functions in the central nervous system ranging from removing
synaptic connections, to maintaining brain homeostasis by monitoring neuronal function, …
synaptic connections, to maintaining brain homeostasis by monitoring neuronal function, …
A platform for discovery: the University of Pennsylvania integrated neurodegenerative disease biobank
…, EB Lee, ER Suh, Y Baek, JL Robinson… - Alzheimer's & …, 2014 - Elsevier
Neurodegenerative diseases (NDs) are defined by the accumulation of abnormal protein
deposits in the central nervous system (CNS), and only neuropathological examination …
deposits in the central nervous system (CNS), and only neuropathological examination …