▪ Abstract Transcriptional regulation in eukaryotes occurs within a chromatin setting and is
strongly influenced by nucleosomal barriers imposed by histone proteins. Among the well-…

The silent information regulator 2 protein (Sir2p) of Saccharomyces cerevisiae is an NAD-dependent
histone deacetylase that plays a critical role in transcriptional silencing. Here, we …

The NAD + -dependent protein deacetylase family, Sir2 (or sirtuins), is important for many
cellular processes including gene silencing, regulation of p53, fatty acid metabolism, cell cycle …

Caloric restriction (CR) extends the life span and health span of a variety of species and
slows the progression of age-related hearing loss (AHL), a common age-related disorder …

Protein tyrosine phosphatases (PTPs) catalyze the hydrolysis of phosphotyrosine from specific
signal-transducing proteins. Although regulatory mechanisms for protein kinases have …

Histone acetylation and phosphorylation have separately been suggested to affect chromatin
structure and gene expression. Here we report that these two modifications are synergistic. …

Silent Information Regulator 2 (Sir2) enzymes (or sirtuins) are NAD + -dependent
deacetylases that modulate gene silencing, aging and energy metabolism. Previous work has …

Conflicting reports have suggested that the silent information regulator 2 (SIR2) protein
family employs NAD + to ADP-ribosylate histones [Tanny, JC, Dowd, GJ, Huang, J., Hilz, H. & …

Calorie restriction (CR) extends life span in diverse species. Mitochondria play a key role in
CR adaptation; however, the molecular details remain elusive. We developed and applied a …

Introduction The circadian clock is a transcriptional oscillator that is thought to couple internal
energetic processes with the solar cycle. Circadian oscillation in activity of nicotinamide …