As high‐throughput techniques including proteomics become more accessible to individual
laboratories, there is an urgent need for a user‐friendly bioinformatics analysis system. Here, …

Inhibitors of histone deacetylases (HDACs) induce growth arrest, differentiation, and apoptosis
of colon cancer cell lines in vitro and have demonstrated anti-cancer efficacy in clinical …

Cetuximab is a monoclonal antibody that targets the human epidermal growth factor receptor
(EGFR). Although approved for use in EGFR-overexpressing advanced colorectal cancer, …

The short-chain fatty acid butyrate, produced by microbial fermentation of dietary fiber in the
large intestine, is a physiological regulator of major pathways of colonic epithelial cell …

Human colorectal cancer cell lines are used widely to investigate tumor biology, experimental
therapy, and biomarkers. However, to what extent these established cell lines represent …

Activation of the canonical TGF-β signaling pathway provides growth inhibitory signals in
the normal intestinal epithelium. Colorectal cancers (CRCs) frequently harbor somatic …

Purpose: Vemurafenib, a selective inhibitor of BRAF V600 , has shown significant activity in
BRAF V600 melanoma but not in less than 10% of metastatic BRAF V600 colorectal cancers (…

Mutations in RAS proteins occur widely in human cancer. Prompted by the confirmation of
KRAS mutation as a predictive biomarker of response to epidermal growth factor receptor (…

The histone deacetylase (HDAC) family of transcriptional co-repressors have emerged as
important regulators of colon cell maturation and transformation. Pharmacological inhibitors of …

The class II Histone deacetylase (HDAC), HDAC4, is expressed in a tissue-specific manner,
and it represses differentiation of specific cell types. We demonstrate here that HDAC4 is …