Here we provide a genome-wide, high-resolution map of the phylogenetic origin of the genome
of most extant laboratory mouse inbred strains. Our analysis is based on the genotypes …

Ovarian clear-cell carcinoma (OCCC) is an aggressive form of ovarian cancer with high
ARID1A mutation rates. Here we present a mutant mouse model of OCCC. We find that ARID1A …

Complex human traits are influenced by variation in regulatory DNA through mechanisms
that are not fully understood. Because regulatory elements are conserved between humans …

Genome-wide association studies (GWAS) have identified >100 independent SNPs that
modulate the risk of type 2 diabetes (T2D) and related traits. However, the pathogenic …

Genotyping microarrays are an important resource for genetic mapping, population genetics,
and monitoring of the genetic integrity of laboratory stocks. We have developed the third …

A key step in the transformation of raw sequencing reads into biological insights is the
trimming of adapter sequences and low-quality bases. Read trimming has been shown to …

Type 2 diabetes (T2D) results from the combined effects of genetic and environmental factors
on multiple tissues over time. Of the >100 variants associated with T2D and related traits in …

Objective Type 2 diabetes (T2D) is a complex disease characterized by pancreatic islet
dysfunction, insulin resistance, and disruption of blood glucose levels. Genome-wide association …

We integrate comeasured gene expression and DNA methylation (DNAme) in 265 human
skeletal muscle biopsies from the FUSION study with >7 million genetic variants and eight …

Significant departures from expected Mendelian inheritance ratios (transmission ratio
distortion, TRD) are frequently observed in both experimental crosses and natural populations. …