For the past decade, the number of molecular targets for approved drugs has been debated.
Here, we reconcile apparently contradictory previous reports into a comprehensive survey, …

ChEMBL is an Open Data database containing binding, functional and ADMET information
for a large number of drug-like bioactive compounds. These data are manually abstracted …

The success of mechanism-based drug discovery depends on the definition of the drug
target. This definition becomes even more important as we try to link drug response to genetic …

Structure-based drug design is now used widely in modern medicinal chemistry. The
application of structural biology to medicinal chemistry has heralded the ‘rational drug design’ …

ChEMBL is an open large-scale bioactivity database ( https://www.ebi.ac.uk/chembl ), previously
described in the 2012 and 2014 Nucleic Acids Research Database Issues. Since then, …

Genome-wide association scans with high-throughput metabolic profiling provide unprecedented
insights into how genetic variation influences metabolism and complex disease. Here …

ChEMBL is an open large-scale bioactivity database (https://www. ebi. ac. uk/chembl), previously
described in the 2012 Nucleic Acids Research Database Issue. Since then, a variety of …

Schistosoma mansoni is responsible for the neglected tropical disease schistosomiasis that
affects 210 million people in 76 countries. Here we present analysis of the 363 megabase …

Chemical probes are powerful reagents with increasing impacts on biomedical research.
However, probes of poor quality or that are used incorrectly generate misleading results. To …

We describe a database of protein structure alignments for homologous families. The database
HOMSTRAD presently contains 130 protein families and 590 aligned structures, which …