User profiles for John P. Richie
John RichiePenn State University College of Medicine Verified email at psu.edu Cited by 10941 |
Dietary methionine influences therapy in mouse cancer models and alters human metabolism
…, Z Dai, MA Reid, DE Cooper, M Lu, JP Richie Jr… - Nature, 2019 - nature.com
Nutrition exerts considerable effects on health, and dietary interventions are commonly
used to treat diseases of metabolic aetiology. Although cancer has a substantial metabolic …
used to treat diseases of metabolic aetiology. Although cancer has a substantial metabolic …
Methionine restriction increases blood glutathione and longevity in F344 rats
JP Richie Jr, Y Leutzinger, S Parthasarathy… - The FASEB …, 1994 - Wiley Online Library
Little is known about the biochemical mechanisms responsible for the biological aging process.
Our previous results and those of others suggest that one possible mechanism is based …
Our previous results and those of others suggest that one possible mechanism is based …
Status of glutathione and other thiols and disulfides in human plasma
WA Kleinman, JP Richie Jr - Biochemical pharmacology, 2000 - Elsevier
While plasma thiols, including homocysteine (HCys), glutathione (GSH), and cysteine (Cys),
are being investigated as potential indicators of disease risk and health status, low levels, …
are being investigated as potential indicators of disease risk and health status, low levels, …
Mushrooms: A rich source of the antioxidants ergothioneine and glutathione
MD Kalaras, JP Richie, A Calcagnotto, RB Beelman - Food chemistry, 2017 - Elsevier
While mushrooms are the highest dietary source for the unique sulfur-containing antioxidant
ergothioneine, little is known regarding levels of the major biological antioxidant glutathione…
ergothioneine, little is known regarding levels of the major biological antioxidant glutathione…
Effects of watercress consumption on metabolism of a tobacco-specific lung carcinogen in smokers.
SS Hecht, FL Chung, JP Richie Jr, SA Akerkar… - … , biomarkers & prevention …, 1995 - AACR
Epidemiological studies indicate that vegetable consumption protects against lung cancer in
humans, but the protective constituents have not been identified. Phenethyl isothiocyanate (…
humans, but the protective constituents have not been identified. Phenethyl isothiocyanate (…
Gender differences in smoking and risk for oral cancer
JE Muscat, JP Richie Jr, S Thompson, EL Wynder - Cancer research, 1996 - AACR
Based on studies that show gender differences in cigarette smoking and lung cancer risk,
we hypothesized that sex differences also exist in the risk for cancer of the oral cavity and …
we hypothesized that sex differences also exist in the risk for cancer of the oral cavity and …
Insulin resistance and its contribution to colon carcinogenesis
…, A Ayonote, JP Richie Jr… - … Biology and Medicine, 2003 - journals.sagepub.com
The insulin resistance-colon cancer hypothesis, stating that insulin resistance may be
associated with the development of colorectal cancer, represents a significant advance in colon …
associated with the development of colorectal cancer, represents a significant advance in colon …
Randomized controlled trial of oral glutathione supplementation on body stores of glutathione
JP Richie, S Nichenametla, W Neidig… - European journal of …, 2015 - Springer
Purpose Glutathione (GSH), the most abundant endogenous antioxidant, is a critical
regulator of oxidative stress and immune function. While oral GSH has been shown to be …
regulator of oxidative stress and immune function. While oral GSH has been shown to be …
Effect of flavoring chemicals on free radical formation in electronic cigarette aerosols
Background Flavoring chemicals, or flavorants, have been used in electronic cigarettes (e-cigarettes)
since their inception; however, little is known about their toxicological effects. Free …
since their inception; however, little is known about their toxicological effects. Free …
Highly reactive free radicals in electronic cigarette aerosols
Electronic cigarette (EC) usage has increased exponentially, but limited data are available
on its potential harmful effects. We tested for the presence of reactive, short-lived free radicals …
on its potential harmful effects. We tested for the presence of reactive, short-lived free radicals …