User profiles for John P. Seymour

John Seymour

University of Texas Health Science Center
Verified email at uth.tmc.edu
Cited by 2951

A materials roadmap to functional neural interface design

…, JR Eles, KA Ludwig, JP Seymour… - Advanced functional …, 2018 - Wiley Online Library
Advancements in neurotechnologies for electrophysiology, neurochemical sensing,
neuromodulation, and optogenetics are revolutionizing scientific understanding of the brain while …

Neural probe design for reduced tissue encapsulation in CNS

JP Seymour, DR Kipke - Biomaterials, 2007 - Elsevier
This study investigated relationships between a microscale neural probe's size and shape
and its chronic reactive tissue response. Parylene-based probes were microfabricated with a …

[HTML][HTML] State-of-the-art MEMS and microsystem tools for brain research

JP Seymour, F Wu, KD Wise, E Yoon - Microsystems & …, 2017 - nature.com
Mapping brain activity has received growing worldwide interest because it is expected to
improve disease treatment and allow for the development of important neuromorphic …

[HTML][HTML] Artifact-free and high-temporal-resolution in vivo opto-electrophysiology with microLED optoelectrodes

K Kim, M Vöröslakos, JP Seymour, KD Wise… - Nature …, 2020 - nature.com
The combination of in vivo extracellular recording and genetic-engineering-assisted optical
stimulation is a powerful tool for the study of neuronal circuits. Precise analysis of complex …

Sharpened and mechanically durable carbon fiber electrode arrays for neural recording

…, EC Bottorff, Z Ouyang, JP Seymour… - … on Neural Systems …, 2021 - ieeexplore.ieee.org
Bioelectric medicine treatments target disorders of the nervous system unresponsive to
pharmacological methods. While current stimulation paradigms effectively treat many disorders, …

Novel multi-sided, microelectrode arrays for implantable neural applications

JP Seymour, NB Langhals, DJ Anderson… - Biomedical …, 2011 - Springer
A new parylene-based microfabrication process is presented for neural recording and drug
delivery applications. We introduce a large design space for electrode placement and …

[HTML][HTML] Multi-channel intraneural vagus nerve recordings with a novel high-density carbon fiber microelectrode array

…, PR Patel, JM Richie, EC Bottorff, JP Seymour… - Scientific Reports, 2020 - nature.com
Autonomic nerves convey essential neural signals that regulate vital body functions. Recording
clearly distinctive physiological neural signals from autonomic nerves will help develop …

The insulation performance of reactive parylene films in implantable electronic devices

JP Seymour, YM Elkasabi, HY Chen, J Lahann… - Biomaterials, 2009 - Elsevier
Parylene-C (poly-chloro-p-xylylene) is an appropriate material for use in an implantable,
microfabricated device. It is hydrophobic, conformally deposited, has a low dielectric constant, …

HectoSTAR μLED Optoelectrodes for Large‐Scale, High‐Precision In Vivo Opto‐Electrophysiology

…, S Oh, SS Parizi, B Hendrix, JP Seymour… - Advanced …, 2022 - Wiley Online Library
Dynamic interactions within and across brain areas underlie behavioral and cognitive
functions. To understand the basis of these processes, the activities of distributed local circuits …

[HTML][HTML] Novel diamond shuttle to deliver flexible neural probe with reduced tissue compression

…, SS Parizi, TM Bruns, E Yoon, JP Seymour - Microsystems & …, 2020 - nature.com
The ability to deliver flexible biosensors through the toughest membranes of the central and
peripheral nervous system is an important challenge in neuroscience and neural …