Gold nanoshell-localized photothermal ablation of prostate tumors in a clinical pilot device study

…, E Wajswol, JS Winoker, JP Sfakianos… - Proceedings of the …, 2019 - National Acad Sciences
Biocompatible gold nanoparticles designed to absorb light at wavelengths of high tissue
transparency have been of particular interest for biomedical applications. The ability of such …

The effect of age and gender on bladder cancer: a critical review of the literature

SF Shariat, JP Sfakianos, MJ Droller… - BJU …, 2010 - Wiley Online Library
While patient age and gender are important factors in the clinical decision‐making for
treating urothelial carcinoma of the bladder (UCB), there are no evidence‐based …

[HTML][HTML] EMT-and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer

…, A Siefker-Radtke, P Sharma, JP Sfakianos… - Nature …, 2018 - nature.com
Cancers infiltrated with T-cells are associated with a higher likelihood of response to PD-1/PD-L1
blockade. Counterintuitively, a correlation between epithelial–mesenchymal transition (…

Genomic characterization of upper tract urothelial carcinoma

JP Sfakianos, EK Cha, G Iyer, SN Scott, EC Zabor… - European urology, 2015 - Elsevier
… Author links open overlay panel John P. Sfakianos a b , Eugene K. Cha a , Gopa Iyer c d , …
Sfakianos was a research fellow in urologic oncology supported by NIH T32-CA82088. …

[PDF][PDF] NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer

B Salomé, JP Sfakianos, D Ranti, J Daza, C Bieber… - Cancer Cell, 2022 - cell.com
Programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1)-blockade
immunotherapies have limited efficacy in the treatment of bladder cancer. Here, we show that …

Effectiveness of adjuvant chemotherapy for locally advanced bladder cancer

…, KD Stensland, E Moshier, JP Sfakianos… - Journal of Clinical …, 2016 - ascopubs.org
Purpose Given that randomized trials exploring adjuvant chemotherapy for bladder cancer
have been underpowered and/or terminated prematurely, yielding inconsistent results and …

The effect of restaging transurethral resection on recurrence and progression rates in patients with nonmuscle invasive bladder cancer treated with intravesical …

JP Sfakianos, PH Kim, AA Hakimi, HW Herr - The Journal of urology, 2014 - Elsevier
Purpose We determined whether restaging resection before initiating induction intravesical
bacillus Calmette-Guérin improves the recurrence-free rate in patients with high risk …

Clonal relatedness and mutational differences between upper tract and bladder urothelial carcinoma

…, EJ Pietzak, JP Sfakianos, A Bagrodia, P Murugan… - Clinical Cancer …, 2019 - AACR
Purpose: To investigate genomic differences between urothelial carcinomas of the upper
tract (UTUC) and bladder (UCB), with a focus on defining the clonal relatedness of temporally …

Genomic predictors of survival in patients with high-grade urothelial carcinoma of the bladder

PH Kim, EK Cha, JP Sfakianos, G Iyer, EC Zabor… - European urology, 2015 - Elsevier
Urothelial carcinoma of the bladder (UCB) is genomically heterogeneous, with frequent
alterations in genes regulating chromatin state, cell cycle control, and receptor kinase signaling. …

[HTML][HTML] Genetic determinants of cisplatin resistance in patients with advanced germ cell tumors

…, BH Lee, W Lee, EK Cha, JP Sfakianos… - Journal of Clinical …, 2016 - ncbi.nlm.nih.gov
Purpose Owing to its exquisite chemotherapy sensitivity, most patients with metastatic germ
cell tumors (GCTs) are cured with cisplatin-based chemotherapy. However, up to 30% of …