Comprehensive knowledge of the brain’s wiring diagram is fundamental for understanding
how the nervous system processes information at both local and global scales. However, with …

Elucidating the cellular architecture of the human cerebral cortex is central to understanding
our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA-…

We assess the usefulness of deferred tax expense in detecting earnings management.
Assuming greater discretion under GAAP than under tax rules, and assuming managers exploit …

Piaget’s theory has not changed fundamentally in the five years since the manuscript for that
edition was completed, but new efforts have been made to make practical use of the theory …

As the size of functional and structural MRI datasets expands, it becomes increasingly
important to establish a baseline from which diagnostic relevance may be determined, a …

Reactive oxygen (RO) has been identified as an important effector in ageing and lifespan
determination 1, 2, 3. The specific cell types, however, in which oxidative damage acts to limit …

Combined pituitary hormone deficiency (CPHD) in man denotes impaired production of growth
hormone (GH) and one or more of the other five anterior pituitary hormones. Mutations of …

The Health and Retirement Study (HRS) is a nationally representative longitudinal survey of
more than 37 000 individuals over age 50 in 23 000 households in the USA. The survey, …

Primary pulmonary hypertension (PPH), characterized by obstruction of pre-capillary pulmonary
arteries, leads to sustained elevation of pulmonary arterial pressure (mean> 25 mm Hg …

Background Idiopathic pulmonary fibrosis is progressive and often fatal; causes of familial
clustering of the disease are unknown. Germ-line mutations in the genes hTERT and hTR, …