A genome-wide association study (GWAS) of educational attainment was conducted in a
discovery sample of 101,069 individuals and a replication sample of 25,490. Three …

Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a phenotype …

General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …

Introduction: Atrial fibrillation (AF) is increasing in prevalence and is associated with
significant morbidity and mortality. The optimal diagnostic and treatment strategies for AF are …

Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor
of a range of morbidities and all-cause mortality. To investigate the genetic determinants of …

Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung
volume and is used to diagnose and monitor lung diseases. We performed genome-wide …

Background and Purpose— Seasonal variation in stroke has long been recognized. To date,
there are minimal published data on seasonal variations in rates of stroke and subsequent …

Objective: To investigate the influence of common and low-frequency genetic variants on
the risk of ischemic stroke (all IS) and etiologic stroke subtypes. Methods: We meta-analyzed …

Genome-wide association studies have previously identified 23 genetic loci associated with
circulating fibrinogen concentration. These studies used HapMap imputation and did not …

Background Many factors contribute to exceptional longevity, with genetics playing a
significant role. However, to date, genetic studies examining exceptional longevity have been …