Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term ‘lncRNAs’ encompasses RNA polymerase I (Pol I), Pol II …

Noncoding RNAs (ncRNA) participate in epigenetic regulation but are poorly understood.
Here we characterize the transcriptional landscape of the four human HOX loci at five base …

Many chromatin-binding proteins and protein complexes that regulate transcription also bind
RNA. One of these, Polycomb repressive complex 2 (PRC2), deposits the H3K27me3 mark …

There is growing recognition that mammalian cells produce many thousands of large intergenic
transcripts 1 , 2 , 3 , 4 . However, the functional significance of these transcripts has been …

Recent advances in high-throughput cDNA sequencing (RNA-seq) can reveal new genes
and splice variants and quantify expression genome-wide in a single assay. The volume and …

Large intervening non-coding RNAs (lincRNAs) are pervasively transcribed in the genome 1
, 2 , 3 yet their potential involvement in human disease is not well understood 4 , 5 . Recent …

The human and mouse genomes contain instructions that specify RNAs and proteins and
govern the timing, magnitude, and cellular context of their production. To better delineate these …

Defining the transcriptional dynamics of a temporal process such as cell differentiation is
challenging owing to the high variability in gene expression between individual cells. Time-…

The central dogma of gene expression is that DNA is transcribed into messenger RNAs, which
in turn serve as the template for protein synthesis. The discovery of extensive transcription …

Large intergenic noncoding RNAs (lincRNAs) are emerging as key regulators of diverse
cellular processes. Determining the function of individual lincRNAs remains a challenge. …