Long-term potentiation and long-term depression are processes that have been widely
studied to understand the molecular basis of information storage in the brain. Glutamate …

The AMPA receptor (AMPAR) GluR2 subunit dictates the critical biophysical properties of the
receptor, strongly influences receptor assembly and trafficking, and plays pivotal roles in a …

Recent work has suggested that some proportion of excitatory synapses on hippocampal
CA1 pyramidal cells that express NMDA receptors (NMDARs) may not express functional …

Glycogen synthase kinase-3 (GSK3) has been implicated in major neurological disorders,
but its role in normal neuronal function is largely unknown. Here we show that GSK3β …

Activity-dependent alteration in synaptic strength is a fundamental property of the vertebrate
central nervous system and is thought to underlie learning and memory. The most …

Here, we show that N-ethylmaleimide–sensitive fusion protein (NSF) interacts directly and
selectively with the intracellular C-terminal domain of the GluR2 subunit of AMPA receptors. …

Postnatal glutamatergic principal neuron synapses are typically presumed to express only
calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here, …

During development, activity-dependent mechanisms are thought to contribute to the
refinement of topographical projections from the thalamus to the cortex. Because activity-…

In this review I discuss the evidence that some glutamatergic synapses exist that lack
surface-expressed postsynaptic AMPA receptors (AMPARs) but contain NMDA receptors opposed …

We investigated the role of PDZ proteins (GRIP, ABP, and PICK1) interacting with the C-terminal
GluR2 by infusing a ct-GluR2 peptide ("pep2-SVKI") into CA1 pyramidal neurons in …