Rationale: T-helper type 2 (Th2) inflammation, mediated by IL-4, IL-5, and IL-13, is considered
the central molecular mechanism underlying asthma, and Th2 cytokines are emerging …

Pulmonary defense against environmental injury depends on airway mucus, which traps
inhaled toxins that are then cleared from the lungs by ciliary beating and cough. This review …

Asthma is one of the most common chronic immunological diseases in humans, affecting
people from childhood to old age. Progress in treating asthma has been relatively slow and …

A humanized murine monoclonal antibody directed to the Fc epsilonR1-binding domain of
human IgE (rhuMAb-E25) has been shown to inhibit the binding of IgE to mast cells without …

Asthma is responsible for considerable global morbidity and health-care costs. Substantial
progress was made against key outcomes such as hospital admissions with asthma and …

Airway inflammation and epithelial remodeling are two key features of asthma. IL-13 and
other cytokines produced during T helper type 2 cell-driven allergic inflammation contribute to …

IgE plays an important role in allergic asthma. We hypothesized that reducing IgE in the
airway mucosa would reduce airway inflammation. Forty-five patients with mild to moderate …

Asthma is a chronic inflammatory airway disease associated with type 2 cytokines
interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus overproduction, …

Background: A clinical model is needed to compare inhaled corticosteroids (ICSs) with
respect to efficacy. Objective: The purpose of this investigation was to compare the relative …

Excessive airway mucus is an important cause of morbidity and mortality in asthma, but the
relationship between accumulation of mucus and goblet cell size, number, and function is …