Loss of protein homeostasis (proteostasis) is a common feature of aging and disease that is
characterized by the appearance of nonnative protein aggregates in various tissues. Protein …

The heat shock response (HSR) is essential for proteostasis and cellular health. In metazoans,
aging is associated with a decline in quality control, thus increasing the risk for protein …

The heat shock response (HSR) was originally discovered as a transcriptional response to
elevated temperature shock and led to the identification of heat shock proteins and heat …

In Caenorhabditis elegans, the programmed repression of the heat shock response (HSR)
accompanies the transition to reproductive maturity, leaving cells vulnerable to environmental …

Mitochondrial and cytosolic proteostasis are of central relevance for cellular stress resistance
and organismal health. Recently, a number of individual cellular programs were described …

Advancing age is the dominant risk factor for most of the major killer diseases in developed
countries. Hence, ameliorating the effects of ageing may prevent multiple diseases …

Age-related changes in cellular metabolism can affect brain homeostasis, creating conditions
that are permissive to the onset and progression of neurodegenerative disorders such as …

The ability to respond rapidly and efficiently to protein misfolding is crucial for development,
reproduction and long-term health. Cells respond to imbalances in cytosolic/nuclear protein …

Increased activity of the heat shock factor, HSF-1, suppresses proteotoxicity and enhances
longevity. However, the precise mechanisms by which HSF-1 promotes lifespan are unclear. …

Age-related changes in cellular metabolism can affect brain homeostasis, creating conditions
that are permissive to the onset and progression of neurodegenerative disorders such as …