The differentiation and maturation of skeletal muscle cells into functional fibers is coordinated
largely by inductive signals which act through discrete intracellular signal transduction …

Neutralizing antibodies that target the receptor-binding domain (RBD) of the SARS-CoV-2
spike protein are among the most promising approaches against COVID-19 1 , 2 . A bispecific …

The differentiation and maturation of skeletal muscle require interactions between signaling
pathways activated by hormones and growth factors and an intrinsic regulatory network …

Interleukin-17A (IL-17A) is a key mediator of protective immunity to yeast and bacterial infections
but also drives the pathogenesis of several autoimmune diseases, such as psoriasis or …

In cancer, the activating transcription factor 2 (ATF2) has pleiotropic functions in cellular
responses to growth stimuli, damage, or inflammation. Due to only limited studies, the …

The proper positioning of organs during development is essential, yet little is known about
the regulation of this process in mammals. Using murine tooth development as a model, we …

Skeletal muscle differentiation, maturation, and regeneration are regulated by interactions
between signaling pathways activated by hormones and growth factors, and intrinsic genetic …

LST1 is a small adaptor protein expressed in leukocytes of myeloid lineage. Due to the
binding to protein tyrosine phosphatases SHP1 and SHP2 it was thought to have negative …

Hypermethylated in cancer 1 (HIC1) represents a prototypic tumor suppressor gene
frequently inactivated by DNA methylation in many types of solid tumors. The gene encodes a …

Increased activity of the Src tyrosine protein kinase that has been observed in a large number
of human malignancies appears to be a promising target for drug therapy. In the present …