User profiles for Jolanda M. Smit

Jolanda Smit

Verified email at umcg.nl
Cited by 7081

[HTML][HTML] Dissecting the cell entry pathway of dengue virus by single-particle tracking in living cells

…, J Wilschut, X Zhuang, JM Smit - PLoS …, 2008 - journals.plos.org
Dengue virus (DENV) is an enveloped RNA virus that causes the most common arthropod-borne
infection worldwide. The mechanism by which DENV infects the host cell remains …

Dengue virus life cycle: viral and host factors modulating infectivity

IA Rodenhuis-Zybert, J Wilschut, JM Smit - Cellular and molecular life …, 2010 - Springer
Dengue virus (DENV 1-4) represents a major emerging arthropod-borne pathogen. All four
DENV serotypes are prevalent in the (sub) tropical regions of the world and infect 50–100 …

Flavivirus cell entry and membrane fusion

JM Smit, B Moesker, I Rodenhuis-Zybert, J Wilschut - Viruses, 2011 - mdpi.com
Flaviviruses, such as dengue virus and West Nile virus, are enveloped viruses that infect cells
through receptor-mediated endocytosis and fusion from within acidic endosomes. The cell …

[HTML][HTML] Immature dengue virus: a veiled pathogen?

…, HY Lei, J Wilschut, JM Smit - PLoS …, 2010 - journals.plos.org
Cells infected with dengue virus release a high proportion of immature prM-containing virions.
In accordance, substantial levels of prM antibodies are found in sera of infected humans. …

Characterization of the early events in dengue virus cell entry by biochemical assays and single-virus tracking

…, RJ Kuhn, J Wilschut, X Zhuang, JM Smit - Journal of …, 2007 - Am Soc Microbiol
In this study, we investigated the cell entry characteristics of dengue virus (DENV) type 2 strain
S1 on mosquito, BHK-15, and BS-C-1 cells. The concentration of virus particles measured …

[HTML][HTML] Development of a highly protective combination monoclonal antibody therapy against Chikungunya virus

…, W Akahata, GJ Nabel, MKS Richter, JM Smit… - PLoS …, 2013 - journals.plos.org
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes global epidemics
of a debilitating polyarthritis in humans. As there is a pressing need for the development …

Neuroinvasive flavivirus infections

GJ Sips, J Wilschut, JM Smit - Reviews in medical virology, 2012 - Wiley Online Library
Flaviviruses, including Dengue, West Nile, Japanese encephalitis, and Tick‐borne encephalitis
virus, are major emerging human pathogens, affecting millions of individuals worldwide. …

[PDF][PDF] Broadly neutralizing alphavirus antibodies bind an epitope on E2 and inhibit entry and egress

…, MKS van Duijl-Richter, RH Fong, KM Kahle, JM Smit… - Cell, 2015 - cell.com
We screened a panel of mouse and human monoclonal antibodies (MAbs) against chikungunya
virus and identified several with inhibitory activity against multiple alphaviruses. Passive …

Functional importance of dengue virus maturation: infectious properties of immature virions

…, J Wilschut, JM Smit - Journal of General …, 2008 - microbiologyresearch.org
Prior to the release of flavivirus particles from infected cells, the viral surface protein prM is
cleaved to M by the cellular enzyme furin. For dengue virus (DENV), this maturation process …

Low-pH-dependent fusion of Sindbis virus with receptor-free cholesterol-and sphingolipid-containing liposomes

JM Smit, R Bittman, J Wilschut - Journal of virology, 1999 - Am Soc Microbiol
There is controversy as to whether the cell entry mechanism of Sindbis virus (SIN) involves
direct fusion of the viral envelope with the plasma membrane at neutral pH or uptake by …