The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex is a structure consisting of
nesprin, SUN, and lamin proteins. A principal function of the LINC complex is anchoring the …

The ability of cells to move in a mechanically coupled, coordinated manner, referred to as
collective cell migration, is central to many developmental, physiological, and …

Vascular endothelial cells (ECs) have been shown to be mechanoresponsive to the forces of
blood flow, including fluid shear stress (FSS), the frictional force of blood on the vessel wall. …

The nucleoskeleton and cytoskeleton are important protein networks that govern cellular
behavior and are connected together by the linker of nucleoskeleton and cytoskeleton (LINC) …

Vinculin is a protein found in both focal adhesions (FAs) and adherens junctions (AJs)
which regulates actin connectivity to these structures. Many studies have demonstrated that …

Nuclear lamins have been considered an important structural element of the nucleus. The
nuclear lamina is thought both to shield DNA from excessive mechanical forces and to …

Epithelial cells lining a gland and cells grown in a soft extracellular matrix polarize with apical
proteins exposed to the lumen and basal proteins in contact with the extracellular matrix. …

Tissue remodeling and shape changes often rely on force-induced cell rearrangements
occurring via cell-cell contact dynamics. Epithelial cell-cell contact shape changes are …

Transmission of cell-generated (ie, endogenous) tension at cell-cell contacts is crucial for
tissue shape changes during morphogenesis and adult tissue repair in tissues like epithelia. E-…

Transmission of cell-generated (ie, endogenous) tension at cell-cell contacts is crucial for
tissue shape changes during morphogenesis and adult tissue repair in tissues such as …